%0 Journal Article %1 ISI:000088162500006 %A Dinner, AR %A Sali, A %A Smith, LJ %A Dobson, CM %A Karplus, M %C 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND %D 2000 %I ELSEVIER SCIENCE LONDON %J TRENDS IN BIOCHEMICAL SCIENCES %K energy experiment surface theory %N 7 %P 331-339 %T Understanding protein folding via free-energy surfaces from theory and experiment %V 25 %X The ability of protein molecules to fold into their highly structured functional states is one of the most remarkable evolutionary achievements of biology. In recent years, our understanding of the way in which this complex self-assembly process takes place has increased dramatically. Much of the reason for this advance has been the development of energy surfaces (landscapes), which allow the folding reaction to be described and visualized in a meaningful manner. Analysis of these surfaces, derived from the constructive interplay between theory and experiment, has led to the development of a unified mechanism for folding and a recognition of the underlying factors that control the rates and products of the folding process.

@article{ISI:000088162500006, abstract = {{The ability of protein molecules to fold into their highly structured functional states is one of the most remarkable evolutionary achievements of biology. In recent years, our understanding of the way in which this complex self-assembly process takes place has increased dramatically. Much of the reason for this advance has been the development of energy surfaces (landscapes), which allow the folding reaction to be described and visualized in a meaningful manner. Analysis of these surfaces, derived from the constructive interplay between theory and experiment, has led to the development of a unified mechanism for folding and a recognition of the underlying factors that control the rates and products of the folding process.}}, added-at = {2009-01-06T09:13:22.000+0100}, address = {{84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND}}, affiliation = {{Dinner, AR (Reprint Author), Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, S Parks Rd, Oxford OX1 3QT, England. Univ Oxford, Oxford Ctr Mol Sci, New Chem Lab, Oxford OX1 3QT, England. Rockefeller Univ, New York, NY 10021 USA. Harvard Univ, Dept Chem \& Biol Chem, Cambridge, MA 02138 USA. Univ Strasbourg 1, Inst Le Bel, Lab Chim Biophys, F-67000 Strasbourg, France.}}, author = {Dinner, AR and Sali, A and Smith, LJ and Dobson, CM and Karplus, M}, biburl = {https://www.bibsonomy.org/bibtex/2879c2336a4d42dc66ebc52c09c382ca8/huiyangsfsu}, cited-references = {{AGASHE VR, 1995, NATURE, V377, P754. BALDWIN RL, 1994, NATURE, V369, P183. BAUM J, 1989, BIOCHEMISTRY-US, V28, P7. BRYNGELSON JD, 1995, PROTEINS, V21, P167. BURLEY SK, 1999, NAT GENET, V23, P151. BURTON RE, 1998, BIOCHEMISTRY-US, V37, P5337. CALLENDER RH, 1998, ANNU REV PHYS CHEM, V49, P173. DAGGETT V, 1996, J MOL BIOL, V257, P430. DAURA X, 1998, J MOL BIOL, V280, P925. DILL KA, 1997, NAT STRUCT BIOL, V4, P10. DINNER AR, 1996, P NATL ACAD SCI USA, V93, P8356. DINNER AR, 1998, NAT STRUCT BIOL, V5, P236. DINNER AR, 1998, PROTEINS, V33, P177. DINNER AR, 1999, J MOL BIOL, V292, P403. DINNER AR, 1999, J PHYS CHEM B, V103, P7976. DINNER AR, 1999, P NATL ACAD SCI USA, V96, P9068. DOBSON CM, 1998, ANGEW CHEM INT EDIT, V37, P868. DOBSON CM, 1998, NAT STRUCT BIOL S, V5, P504. DOBSON CM, 1999, CURR OPIN STRUC BIOL, V9, P92. DOBSON CM, 1999, TRENDS BIOCHEM SCI, V24, P329. DUAN Y, 1998, SCIENCE, V282, P740. DYSON HJ, 1996, ANNU REV PHYS CHEM, V47, P369. DYSON HJ, 1998, NAT STRUCT BIOL S, V5, P499. EATON WA, 1997, CURR OPIN STRUC BIOL, V7, P10. ELLIS RJ, 1999, CURR OPIN STRUC BIOL, V9, P102. FERGUSON N, 1999, J MOL BIOL, V286, P1597. FERSHT A, 1999, STRUCTURE MECH PROTE. FERSHT AR, 2000, P NATL ACAD SCI USA, V97, P1525. FINKELSTEIN AV, 1997, FOLD DES, V2, P115. GUTIN AM, 1995, BIOCHEMISTRY-US, V34, P3066. HECHT MH, 1990, SCIENCE, V249, P884. IBARRAMOLERO B, 1996, BIOCHEMISTRY-US, V35, P14689. ITZHAKI LS, 1995, J MOL BIOL, V254, P260. JACKSON SE, 1998, FOLD DES, V3, R81. KAMTEKAR S, 1993, SCIENCE, V262, P1680. KARPLUS M, 1976, NATURE, V260, P404. KARPLUS M, 1997, FOLD DES, V2, P569. KHORASANIZADEH S, 1996, NAT STRUCT BIOL, V3, P193. KIEFHABER T, 1995, P NATL ACAD SCI USA, V92, P9029. KIM PS, 1990, ANNU REV BIOCHEM, V59, P631. KULKARNI SK, 1999, PROTEIN SCI, V8, P35. KUWAJIMA K, 1996, FASEB J, V10, P102. LAZARIDIS T, 1997, SCIENCE, V278, P1928. MATAGNE A, 1997, J MOL BIOL, V267, P1068. MATAGNE A, 2000, J MOL BIOL, V297, P193. MOROZOVAROCHE LA, 1999, J MOL BIOL, V289, P1055. MUNOZ V, 1999, P NATL ACAD SCI USA, V96, P11311. PLAXCO KW, 1996, CURR OPIN STRUC BIOL, V6, P630. PLAXCO KW, 1998, J MOL BIOL, V277, P985. PLAXCO KW, 1999, NAT STRUCT BIOL, V6, P554. PTITSYN OB, 1995, CURR OPIN STRUC BIOL, V5, P74. RADFORD SE, 1992, NATURE, V358, P302. RADFORD SE, 1999, CELL, V97, P291. ROY S, 1997, J AM CHEM SOC, V119, P5302. SABELKO J, 1999, P NATL ACAD SCI USA, V96, P6031. SALI A, 1994, NATURE, V369, P248. SCHAEFER M, 1998, J MOL BIOL, V284, P835. SCHMID FX, 1992, PROTEIN FOLDING, P197. SEGEL DJ, 1999, J MOL BIOL, V288, P489. SHORTLE D, 1996, FASEB J, V10, P27. SIPPL MJ, 1999, PROTEINS, V3, P226. SMITH LJ, 1993, J MOL BIOL, V229, P930. SMITH LJ, 1996, FOLDING DESIGN, V1, P95. SOCCI ND, 1996, J CHEM PHYS, V104, P5860. SOSNICK TR, 1994, NAT STRUCT BIOL, V1, P149. THOMAS PJ, 1995, TRENDS BIOCHEM SCI, V20, P456. WOLYNES PG, 1995, SCIENCE, V267, P1619. ZHOU YQ, 1999, NATURE, V401, P400.}}, doc-delivery-number = {{334AG}}, interhash = {7e20505e54ad1b1712a0161d7f54c748}, intrahash = {879c2336a4d42dc66ebc52c09c382ca8}, issn = {{0968-0004}}, journal = {{TRENDS IN BIOCHEMICAL SCIENCES}}, journal-iso = {{Trends Biochem.Sci.}}, keywords = {energy experiment surface theory}, keywords-plus = {{MOLECULAR-DYNAMICS SIMULATION; SINGLE-DOMAIN PROTEINS; MOLTEN GLOBULE STATE; NONPOLAR AMINO-ACIDS; TRANSITION-STATE; HEN LYSOZYME; HYDROPHOBIC COLLAPSE; ALPHA-LACTALBUMIN; MULTIPLE PATHWAYS; MODEL PROTEINS}}, language = {{English}}, month = {{JUL}}, number = {{7}}, number-of-cited-references = {{68}}, pages = {{331-339}}, publisher = {{ELSEVIER SCIENCE LONDON}}, subject-category = {{Biochemistry \& Molecular Biology}}, times-cited = {{226}}, timestamp = {2009-01-06T09:13:22.000+0100}, title = {{Understanding protein folding via free-energy surfaces from theory and experiment}}, type = {{Article}}, unique-id = {{ISI:000088162500006}}, volume = {{25}}, year = {{2000}} }