Article,

Maximum of the weighted Kaplan-Meier tests with application to cancer prevention and screening trials

, and .
Biometrics, 57 (3): 837-843 (September 2001)

Abstract

A class of maximum weighted Kaplan-Meier test statistics is described where the weight functions are chosen from a family of smooth functions. The investigated test statistic is robust and sensitive to a variety of alternatives that are often observed in cancer prevention and screening trials. A simulation study is performed to compare the size and power properties between the proposed test statistics and some existing ones. We illustrate the procedure using data from a clinical trial of a breast cancer screening program.

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