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The Evolution of Stochastic Regular Motifs for Protein Sequences

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New Generation Computing, 20 (2): 187--213 (февраля 2002)

Аннотация

Stochastic regular motifs are evolved for protein sequences using genetic programming. The motif language, SRE-DNA, is a stochastic regular expression language suitable for denoting biosequences. Three restricted versions of SRE-DNA are used as target languages for evolved motifs. The genetic programming experiments are implemented in DCTG-GP, which is a genetic programming system that uses logic--based attribute grammars to define the target language for evolved programs. Earlier preliminary work tested SRE-DNA's viability as a representation language for aligned protein sequences. This work establishes that SRE-DNA is also suitable for evolving motifs for unaligned sets of sequences.

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