We recently described the capsule null locus (cnl) of constitutively unencapsulated Neisseria meningitidis clonal lineages. cnl meningococci were recovered from healthy carriers at high frequency. We here report on the first case of invasive disease caused by cnl meningococci in a severely immunosuppressed patient with chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. The sequence type 845 strain was extensively typed and, furthermore, shown to be sensitive to serum bactericidal activity.
%0 Journal Article
%1 vogel_bacteremia_2004
%A Vogel, Ulrich
%A Claus, Heike
%A von Müller, Lutz
%A Bunjes, Donald
%A Elias, Johannes
%A Frosch, Matthias
%D 2004
%J Journal of Clinical Microbiology
%K Adult, Bacteremia, Bacterial Blood Capsules, Cell Chromosome Disease, Graft Host Humans, Mapping, Neisseria Peripheral Stem Transplantation meningitidis, vs
%N 7
%P 2898--901
%R 15243035
%T Bacteremia in an immunocompromised patient caused by a commensal Neisseria meningitidis strain harboring the capsule null locus (cnl)
%V 42
%X We recently described the capsule null locus (cnl) of constitutively unencapsulated Neisseria meningitidis clonal lineages. cnl meningococci were recovered from healthy carriers at high frequency. We here report on the first case of invasive disease caused by cnl meningococci in a severely immunosuppressed patient with chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. The sequence type 845 strain was extensively typed and, furthermore, shown to be sensitive to serum bactericidal activity.
@article{vogel_bacteremia_2004,
abstract = {We recently described the capsule null locus (cnl) of constitutively unencapsulated Neisseria meningitidis clonal lineages. cnl meningococci were recovered from healthy carriers at high frequency. We here report on the first case of invasive disease caused by cnl meningococci in a severely immunosuppressed patient with chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. The sequence type 845 strain was extensively typed and, furthermore, shown to be sensitive to serum bactericidal activity.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Vogel, Ulrich and Claus, Heike and von Müller, Lutz and Bunjes, Donald and Elias, Johannes and Frosch, Matthias},
biburl = {https://www.bibsonomy.org/bibtex/2fdc238d6dc7fd07ef3a86d3ebbb5d47e/jelias},
doi = {15243035},
interhash = {98f508f43dcd5237145ecd09292d5e23},
intrahash = {fdc238d6dc7fd07ef3a86d3ebbb5d47e},
issn = {0095-1137},
journal = {Journal of Clinical Microbiology},
keywords = {Adult, Bacteremia, Bacterial Blood Capsules, Cell Chromosome Disease, Graft Host Humans, Mapping, Neisseria Peripheral Stem Transplantation meningitidis, vs},
month = jul,
note = {{PMID:} 15243035},
number = 7,
pages = {2898--901},
timestamp = {2011-03-11T10:06:27.000+0100},
title = {Bacteremia in an immunocompromised patient caused by a commensal Neisseria meningitidis strain harboring the capsule null locus (cnl)},
volume = 42,
year = 2004
}