PURPOSE: The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that vascular endothelial growth factor-C (VEGF-C), and its receptor VEGFR-3, may play a pivotal role in the promotion of metastasis to regional lymph nodes. This study was designed to detect and evaluate whether the expression of VEGFR-3 or its soluble form plays a role in metastatic malignant melanoma and to determine the relationship with clinicopathological parameters and patients outcome. EXPERIMENTAL DESIGN: VEGFR-3 expression on melanoma tumour was evaluated by immunohistochemical study. Using a sensitive enzyme-linked immunosorbent assay, sVEGFR-3 was measured in sera of 60 metastatic melanoma patients in comparison with 30 healthy controls. RESULTS: Immunohistochemical study demonstrated a high expression of VEGFR-3 in melanoma cells. Median level of pre-treatment sVEGFR-3 was significantly higher (p=0.00001) in melanoma
%0 Journal Article
%1 Mouawad.2009
%A Mouawad, R.
%A Spano, J. P.
%A Comperat, E.
%A Capron, F.
%A Khayat, D.
%D 2009
%J Eur.J.Cancer
%K Assay C Endothelial Enzyme-Linked Factor France Growth Immunosorbent Laboratories Medical Oncology Prognosis Research Vascular cells
%N 8
%P 1407-1414
%T Tumoural expression and circulating level of VEGFR-3 (Flt-4) in metastatic melanoma patients: correlation with clinical parameters and outcome
%U PM:19157860
%V 45
%X PURPOSE: The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that vascular endothelial growth factor-C (VEGF-C), and its receptor VEGFR-3, may play a pivotal role in the promotion of metastasis to regional lymph nodes. This study was designed to detect and evaluate whether the expression of VEGFR-3 or its soluble form plays a role in metastatic malignant melanoma and to determine the relationship with clinicopathological parameters and patients outcome. EXPERIMENTAL DESIGN: VEGFR-3 expression on melanoma tumour was evaluated by immunohistochemical study. Using a sensitive enzyme-linked immunosorbent assay, sVEGFR-3 was measured in sera of 60 metastatic melanoma patients in comparison with 30 healthy controls. RESULTS: Immunohistochemical study demonstrated a high expression of VEGFR-3 in melanoma cells. Median level of pre-treatment sVEGFR-3 was significantly higher (p=0.00001) in melanoma
@article{Mouawad.2009,
abstract = {PURPOSE: The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that vascular endothelial growth factor-C (VEGF-C), and its receptor VEGFR-3, may play a pivotal role in the promotion of metastasis to regional lymph nodes. This study was designed to detect and evaluate whether the expression of VEGFR-3 or its soluble form plays a role in metastatic malignant melanoma and to determine the relationship with clinicopathological parameters and patients outcome. EXPERIMENTAL DESIGN: VEGFR-3 expression on melanoma tumour was evaluated by immunohistochemical study. Using a sensitive enzyme-linked immunosorbent assay, sVEGFR-3 was measured in sera of 60 metastatic melanoma patients in comparison with 30 healthy controls. RESULTS: Immunohistochemical study demonstrated a high expression of VEGFR-3 in melanoma cells. Median level of pre-treatment sVEGFR-3 was significantly higher (p=0.00001) in melanoma},
added-at = {2010-02-05T11:28:39.000+0100},
author = {Mouawad, R. and Spano, J. P. and Comperat, E. and Capron, F. and Khayat, D.},
biburl = {https://www.bibsonomy.org/bibtex/2f884e45818fceca6752fd842542c8094/kanefendt},
interhash = {9973c74f2a6c0fffb54c299f689f3472},
intrahash = {f884e45818fceca6752fd842542c8094},
journal = {Eur.J.Cancer},
keywords = {Assay C Endothelial Enzyme-Linked Factor France Growth Immunosorbent Laboratories Medical Oncology Prognosis Research Vascular cells},
number = 8,
pages = {1407-1414},
timestamp = {2010-02-05T11:28:51.000+0100},
title = {Tumoural expression and circulating level of VEGFR-3 (Flt-4) in metastatic melanoma patients: correlation with clinical parameters and outcome},
url = {PM:19157860},
volume = 45,
year = 2009
}