The establishment of Neisseria meningitidis serogroup W135 of the clonal complex ET-37/ST-11 as an epidemic clone and the persistence of serogroup A isolates in Burkina Faso
We analyzed 48 invasive isolates of Neisseria meningitidis that were isolated from meningitis cases in Burkina Faso (April 2002 to April 2003). Thirty-nine of these isolates had the phenotype (serogroup:serotype:serosubtype) W135:2a:P1.5,2, eight isolates were A:4:P1.9 and one isolate was nongroupable:nonserotypable:nonserosubtypable. Genotyping of meningococcal isolates showed that W135 isolates belonged to the sequence type (ST)-11. The nongroupable isolate was of genogroup W135 and belonged to ST-192. Isolates of serogroup A belonged to ST-2859 (a member of the subgroup III/ST-5 clonal complex). W135 (ST-11) isolates involved in meningitis outbreaks in Burkina Faso differed from those involved in the Hajj-2000 associated outbreak by their pulsed-field gel electrophoresis profile. These data confirm the changing epidemiology of meningococcal infection in Burkina Faso with the establishment and expansion of serogroup W135 N. meningitidis strains of the ET-37/ST-11 clonal complex, as well as the emergence of a new clone within the subgroup III/ST-5 clonal complex.
%0 Journal Article
%1 njanpop-lafourcade_establishment_2005
%A Njanpop-Lafourcade, Berthe-Marie
%A du Châtelet, Isabelle Parent
%A Sanou, Oumar
%A Alonso, Jean-Michel
%A Taha, Muhamed-Kheir
%D 2005
%J Microbes and Infection / Institut Pasteur
%K Adolescent, Bacterial Burkina Child, Communicable Diseases, Emerging, Epidemiology, Faso, Female, Genotype, Humans, Infant, Male, Meningitis, Meningococcal, Molecular, Neisseria Phenotype, Population Preschool, Prospective Serogroup Studies Surveillance, Techniques, Typing W-135, meningitidis,
%N 4
%P 645--649
%R 10.1016/j.micinf.2005.01.003
%T The establishment of Neisseria meningitidis serogroup W135 of the clonal complex ET-37/ST-11 as an epidemic clone and the persistence of serogroup A isolates in Burkina Faso
%U http://www.ncbi.nlm.nih.gov/pubmed/15823512
%V 7
%X We analyzed 48 invasive isolates of Neisseria meningitidis that were isolated from meningitis cases in Burkina Faso (April 2002 to April 2003). Thirty-nine of these isolates had the phenotype (serogroup:serotype:serosubtype) W135:2a:P1.5,2, eight isolates were A:4:P1.9 and one isolate was nongroupable:nonserotypable:nonserosubtypable. Genotyping of meningococcal isolates showed that W135 isolates belonged to the sequence type (ST)-11. The nongroupable isolate was of genogroup W135 and belonged to ST-192. Isolates of serogroup A belonged to ST-2859 (a member of the subgroup III/ST-5 clonal complex). W135 (ST-11) isolates involved in meningitis outbreaks in Burkina Faso differed from those involved in the Hajj-2000 associated outbreak by their pulsed-field gel electrophoresis profile. These data confirm the changing epidemiology of meningococcal infection in Burkina Faso with the establishment and expansion of serogroup W135 N. meningitidis strains of the ET-37/ST-11 clonal complex, as well as the emergence of a new clone within the subgroup III/ST-5 clonal complex.
@article{njanpop-lafourcade_establishment_2005,
abstract = {We analyzed 48 invasive isolates of Neisseria meningitidis that were isolated from meningitis cases in Burkina Faso {(April} 2002 to April 2003). Thirty-nine of these isolates had the phenotype (serogroup:serotype:serosubtype) {W135:2a:P1.5,2,} eight isolates were {A:4:P1.9} and one isolate was nongroupable:nonserotypable:nonserosubtypable. Genotyping of meningococcal isolates showed that W135 isolates belonged to the sequence type {(ST)-11.} The nongroupable isolate was of genogroup W135 and belonged to {ST-192.} Isolates of serogroup A belonged to {ST-2859} (a member of the subgroup {III/ST-5} clonal complex). W135 {(ST-11)} isolates involved in meningitis outbreaks in Burkina Faso differed from those involved in the Hajj-2000 associated outbreak by their pulsed-field gel electrophoresis profile. These data confirm the changing epidemiology of meningococcal infection in Burkina Faso with the establishment and expansion of serogroup W135 N. meningitidis strains of the {ET-37/ST-11} clonal complex, as well as the emergence of a new clone within the subgroup {III/ST-5} clonal complex.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {{Njanpop-Lafourcade}, {Berthe-Marie} and du Châtelet, Isabelle Parent and Sanou, Oumar and Alonso, {Jean-Michel} and Taha, {Muhamed-Kheir}},
biburl = {https://www.bibsonomy.org/bibtex/2c51f38195ef894b0d2102736252e07d7/jelias},
doi = {10.1016/j.micinf.2005.01.003},
interhash = {99a4d31f62080fa2da9f38d367260953},
intrahash = {c51f38195ef894b0d2102736252e07d7},
issn = {1286-4579},
journal = {Microbes and Infection / Institut Pasteur},
keywords = {Adolescent, Bacterial Burkina Child, Communicable Diseases, Emerging, Epidemiology, Faso, Female, Genotype, Humans, Infant, Male, Meningitis, Meningococcal, Molecular, Neisseria Phenotype, Population Preschool, Prospective Serogroup Studies Surveillance, Techniques, Typing W-135, meningitidis,},
month = apr,
note = {{PMID:} 15823512},
number = 4,
pages = {645--649},
timestamp = {2011-03-11T10:05:39.000+0100},
title = {The establishment of Neisseria meningitidis serogroup W135 of the clonal complex {ET-37/ST-11} as an epidemic clone and the persistence of serogroup A isolates in Burkina Faso},
url = {http://www.ncbi.nlm.nih.gov/pubmed/15823512},
volume = 7,
year = 2005
}