%0 Journal Article %1 Ma2017Systems %A Ma, Qian %A Zhang, Quanwei %A Xu, Qingyang %A Zhang, Chenglin %A Li, Yanjun %A Fan, Xiaoguang %A Xie, Xixian %A Chen, Ning %D 2017 %J Synthetic and systems biotechnology %K in-silico metabolic-engineering systems-biology %N 2 %P 87--96 %T Systems metabolic engineering strategies for the production of amino acids. %U http://view.ncbi.nlm.nih.gov/pubmed/29062965 %V 2 %X Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-focused approaches, systems biology-based approaches, evolutionary approaches and their applications in two major amino acid producing microorganisms: Corynebacterium glutamicum and Escherichia coli, are summarized.

@article{Ma2017Systems, abstract = {Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-focused approaches, systems biology-based approaches, evolutionary approaches and their applications in two major amino acid producing microorganisms: Corynebacterium glutamicum and Escherichia coli, are summarized.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {Ma, Qian and Zhang, Quanwei and Xu, Qingyang and Zhang, Chenglin and Li, Yanjun and Fan, Xiaoguang and Xie, Xixian and Chen, Ning}, biburl = {https://www.bibsonomy.org/bibtex/2b03b6ee7c6bbe12d871d7a86e8636f4f/karthikraman}, citeulike-article-id = {14510684}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/29062965}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=29062965}, interhash = {a742aa48a7518b5f872ccacd54c55cd0}, intrahash = {b03b6ee7c6bbe12d871d7a86e8636f4f}, issn = {2405-805X}, journal = {Synthetic and systems biotechnology}, keywords = {in-silico metabolic-engineering systems-biology}, month = jun, number = 2, pages = {87--96}, pmid = {29062965}, posted-at = {2018-01-01 08:21:29}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Systems metabolic engineering strategies for the production of amino acids.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/29062965}, volume = 2, year = 2017 }