Subjects were scanned in a single functional MRI (fMRI) experiment
that enabled us to localize cortical regions in each subject in the
occipital and temporal lobes that responded significantly in a variety
of contrasts: faces>objects, body parts>objects, scenes>objects,
objects>scrambled objects, and moving>stationary stimuli. The resulting
activation maps were co-registered across subjects using spherical
surface coordinates Fischl et al., Hum Brain Mapp 1999;8:272-284
to produce a "percentage overlap map" indicating the percentage of
subjects who showed a significant response for each contrast at each
point on the surface. Prominent among the overlapping activations
in these contrasts were the fusiform face area (FFA), extrastriate
body area (EBA), parahippocampal place area (PPA), lateral occipital
complex (LOC), and MT+/V5; only a few other areas responded consistently
across subjects in these contrasts. Another analysis showed that
the spatial profile of the selective response drops off quite sharply
outside the standard borders of the FFA and PPA (less so for the
EBA and MT+/V5), indicating that these regions are not simply peaks
of very broad selectivities spanning centimeters of cortex, but fairly
discrete regions of cortex with distinctive functional profiles.
The data also yielded a surprise that challenges our understanding
of the function of area MT+: a higher response to body parts than
to objects. The anatomical consistency of each of our functionally
defined regions across subjects and the spatial sharpness of their
activation profiles within subjects highlight the fact that these
regions constitute replicable and distinctive landmarks in the functional
organization of the human brain.
%0 Journal Article
%1 Spiridon2006
%A Spiridon, Mona
%A Fischl, Bruce
%A Kanwisher, Nancy
%D 2006
%J Human Brain Mapping
%K Adult; Brain Cerebral Computer-Assisted; Cortex; Female; Humans; Image Imaging; Magnetic Male; Mapping; Pattern Photic Processing, Recognition, Resonance Stimulation Visual;
%P 77--89
%R 10.1002/hbm.20169
%T Location and spatial profile of category-specific regions in human
extrastriate cortex.
%U http://dx.doi.org/10.1002/hbm.20169
%V 27
%X Subjects were scanned in a single functional MRI (fMRI) experiment
that enabled us to localize cortical regions in each subject in the
occipital and temporal lobes that responded significantly in a variety
of contrasts: faces>objects, body parts>objects, scenes>objects,
objects>scrambled objects, and moving>stationary stimuli. The resulting
activation maps were co-registered across subjects using spherical
surface coordinates Fischl et al., Hum Brain Mapp 1999;8:272-284
to produce a "percentage overlap map" indicating the percentage of
subjects who showed a significant response for each contrast at each
point on the surface. Prominent among the overlapping activations
in these contrasts were the fusiform face area (FFA), extrastriate
body area (EBA), parahippocampal place area (PPA), lateral occipital
complex (LOC), and MT+/V5; only a few other areas responded consistently
across subjects in these contrasts. Another analysis showed that
the spatial profile of the selective response drops off quite sharply
outside the standard borders of the FFA and PPA (less so for the
EBA and MT+/V5), indicating that these regions are not simply peaks
of very broad selectivities spanning centimeters of cortex, but fairly
discrete regions of cortex with distinctive functional profiles.
The data also yielded a surprise that challenges our understanding
of the function of area MT+: a higher response to body parts than
to objects. The anatomical consistency of each of our functionally
defined regions across subjects and the spatial sharpness of their
activation profiles within subjects highlight the fact that these
regions constitute replicable and distinctive landmarks in the functional
organization of the human brain.
@article{Spiridon2006,
abstract = {Subjects were scanned in a single functional MRI (fMRI) experiment
that enabled us to localize cortical regions in each subject in the
occipital and temporal lobes that responded significantly in a variety
of contrasts: faces>objects, body parts>objects, scenes>objects,
objects>scrambled objects, and moving>stationary stimuli. The resulting
activation maps were co-registered across subjects using spherical
surface coordinates [Fischl et al., Hum Brain Mapp 1999;8:272-284]
to produce a "percentage overlap map" indicating the percentage of
subjects who showed a significant response for each contrast at each
point on the surface. Prominent among the overlapping activations
in these contrasts were the fusiform face area (FFA), extrastriate
body area (EBA), parahippocampal place area (PPA), lateral occipital
complex (LOC), and MT+/V5; only a few other areas responded consistently
across subjects in these contrasts. Another analysis showed that
the spatial profile of the selective response drops off quite sharply
outside the standard borders of the FFA and PPA (less so for the
EBA and MT+/V5), indicating that these regions are not simply peaks
of very broad selectivities spanning centimeters of cortex, but fairly
discrete regions of cortex with distinctive functional profiles.
The data also yielded a surprise that challenges our understanding
of the function of area MT+: a higher response to body parts than
to objects. The anatomical consistency of each of our functionally
defined regions across subjects and the spatial sharpness of their
activation profiles within subjects highlight the fact that these
regions constitute replicable and distinctive landmarks in the functional
organization of the human brain.},
added-at = {2007-12-16T20:00:22.000+0100},
author = {Spiridon, Mona and Fischl, Bruce and Kanwisher, Nancy},
biburl = {https://www.bibsonomy.org/bibtex/2f37cb7d1d3db0424cd279e1dd8bf69de/perceptron},
doi = {10.1002/hbm.20169},
interhash = {ab65e13af8165fcc7e91144b23804f65},
intrahash = {f37cb7d1d3db0424cd279e1dd8bf69de},
journal = {Human Brain Mapping},
keywords = {Adult; Brain Cerebral Computer-Assisted; Cortex; Female; Humans; Image Imaging; Magnetic Male; Mapping; Pattern Photic Processing, Recognition, Resonance Stimulation Visual;},
pages = {77--89},
pmid = {15966002},
timestamp = {2007-12-16T20:00:26.000+0100},
title = {Location and spatial profile of category-specific regions in human
extrastriate cortex.},
url = {http://dx.doi.org/10.1002/hbm.20169},
volume = 27,
year = 2006
}