The development of a mercury-195m/gold-195m radionuclide generator system is described, together with the results of preliminary experiments in animals and in man. The daughter radionuclide has half-life of 30.5 s with a principal gamma emission at 262 keV, ideal for use with the multicrystal camera but suitable also in conjunction with the Anger design. The half-life of the parent radionuclide is 40 h. The eluant in current use is 2.5 mM sodium cyanide, the column being stored under 2\% sodium nitrate solution when not in use to prevent radiation damage. Generators capable of delivering 550 MBq of 195 Au m in a 0.4 ml bolus have been used for first-pass nuclear angiocardiography, the half-life being long enough to permit administration via peripheral intravenous injection. The radiation dose associated with this radionuclide is much lower than that from conventional 99 Tc m -labelled radiopharmaceuticals, permitting multiple sequential studies, even on children.
%0 Journal Article
%1 Elliott1983195Hgm195Aum
%A Elliott, A. T.
%A Dymond, D. S.
%A Stone, D. L.
%A Flatman, W.
%A Bett, R.
%A Cuninghame, J. G.
%A Sims, H. E.
%A Willis, H. H.
%D 1983
%J Physics in Medicine and Biology
%K radiation family
%N 2
%P 139+
%R 10.1088/0031-9155/28/2/003
%T A 195Hgm-195Aum generator for use in first-pass nuclear angiocardiography
%U http://dx.doi.org/10.1088/0031-9155/28/2/003
%V 28
%X The development of a mercury-195m/gold-195m radionuclide generator system is described, together with the results of preliminary experiments in animals and in man. The daughter radionuclide has half-life of 30.5 s with a principal gamma emission at 262 keV, ideal for use with the multicrystal camera but suitable also in conjunction with the Anger design. The half-life of the parent radionuclide is 40 h. The eluant in current use is 2.5 mM sodium cyanide, the column being stored under 2\% sodium nitrate solution when not in use to prevent radiation damage. Generators capable of delivering 550 MBq of 195 Au m in a 0.4 ml bolus have been used for first-pass nuclear angiocardiography, the half-life being long enough to permit administration via peripheral intravenous injection. The radiation dose associated with this radionuclide is much lower than that from conventional 99 Tc m -labelled radiopharmaceuticals, permitting multiple sequential studies, even on children.
@article{Elliott1983195Hgm195Aum,
abstract = {The development of a mercury-195m/gold-195m radionuclide generator system is described, together with the results of preliminary experiments in animals and in man. The daughter radionuclide has half-life of 30.5 s with a principal gamma emission at 262 keV, ideal for use with the multicrystal camera but suitable also in conjunction with the Anger design. The half-life of the parent radionuclide is 40 h. The eluant in current use is 2.5 mM sodium cyanide, the column being stored under 2\% sodium nitrate solution when not in use to prevent radiation damage. Generators capable of delivering 550 MBq of 195 Au m in a 0.4 ml bolus have been used for first-pass nuclear angiocardiography, the half-life being long enough to permit administration via peripheral intravenous injection. The radiation dose associated with this radionuclide is much lower than that from conventional 99 Tc m -labelled radiopharmaceuticals, permitting multiple sequential studies, even on children.},
added-at = {2018-06-18T21:23:34.000+0200},
author = {Elliott, A. T. and Dymond, D. S. and Stone, D. L. and Flatman, W. and Bett, R. and Cuninghame, J. G. and Sims, H. E. and Willis, H. H.},
biburl = {https://www.bibsonomy.org/bibtex/26e49a25eb8283ed3f61a4407a7e6a549/pbett},
citeulike-article-id = {13693284},
citeulike-linkout-0 = {http://dx.doi.org/10.1088/0031-9155/28/2/003},
citeulike-linkout-1 = {http://iopscience.iop.org/0031-9155/28/2/003},
day = 01,
doi = {10.1088/0031-9155/28/2/003},
interhash = {b31bfc1c01cb72d7e28268eb237bcee6},
intrahash = {6e49a25eb8283ed3f61a4407a7e6a549},
issn = {0031-9155},
journal = {Physics in Medicine and Biology},
keywords = {radiation family},
month = feb,
number = 2,
pages = {139+},
posted-at = {2015-08-03 10:04:23},
priority = {2},
timestamp = {2018-06-22T18:35:16.000+0200},
title = {A 195Hgm-195Aum generator for use in first-pass nuclear angiocardiography},
url = {http://dx.doi.org/10.1088/0031-9155/28/2/003},
volume = 28,
year = 1983
}