%0 Journal Article %1 display:flex).nav-primary__list-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;padding-top:0.nav-primary__itemfloat:left;font-family:"Noto %A Landegren, Nils %A Rosen, Lindsey B %A Freyhult, Eva %A Eriksson, Daniel %A Fall, Tove %A Smith, Gustav %A Ferre, Elise M N %A Brodin, Petter %A Sharon, Donald %A Snyder, Michael %A Lionakis, Michail %A Anderson, mark %A Kämpe, Olle %D 2019 %J ELife %K AIRE %R 10.7554/eLife.43578 %T Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'. %V 8 %X The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.

@article{display:flex){.nav-primary__list{-ms-flex-align:center;align-items:center;display:-ms-flexbox;display:flex;padding-top:0}}.nav-primary__item{float:left;font-family:"Noto, abstract = {The AIRE gene plays a key role in the development of central immune tolerance by promoting thymic presentation of tissue-specific molecules. Patients with AIRE-deficiency develop multiple autoimmune manifestations and display autoantibodies against the affected tissues. In 2016 it was reported that: i) the spectrum of autoantibodies in patients with AIRE-deficiency is much broader than previously appreciated; ii) neutralizing autoantibodies to type I interferons (IFNs) could provide protection against type 1 diabetes in these patients (Meyer et al., 2016). We attempted to replicate these new findings using a similar experimental approach in an independent patient cohort, and found no evidence for either conclusion.}, added-at = {2020-04-02T19:13:06.000+0200}, author = {Landegren, Nils and Rosen, Lindsey B and Freyhult, Eva and Eriksson, Daniel and Fall, Tove and Smith, Gustav and Ferre, Elise M N and Brodin, Petter and Sharon, Donald and Snyder, Michael and Lionakis, Michail and Anderson, mark and Kämpe, Olle}, biburl = {https://www.bibsonomy.org/bibtex/2e2a935e30d8ef54c990ad9af5d513507/lkanth}, description = {Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' | eLife}, doi = {10.7554/eLife.43578}, interhash = {b6921fa8be5150bff61e4ee20d08765a}, intrahash = {e2a935e30d8ef54c990ad9af5d513507}, issn = {2050-084X}, journal = {ELife}, keywords = {AIRE}, month = {June}, timestamp = {2020-04-02T19:13:06.000+0200}, title = {Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.}, volume = 8, year = 2019 }