%0 Journal Article %1 noauthororeditor %A et al, Arkin %D 2021 %J Journal of Investigative Dermatology %K Covid-19 %R 10.1016/j.jid.2021.05.024 %T From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio %U /brokenurl#10.1016/j.jid.2021.05.024 %X Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemicassociated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

@article{noauthororeditor, abstract = {Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemicassociated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.}, added-at = {2021-10-01T14:12:28.000+0200}, author = {et al, Arkin}, biburl = {https://www.bibsonomy.org/bibtex/210e9997f672c9cdb4d44afa8c5c07ab5/lkanth}, description = {From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio}, doi = {10.1016/j.jid.2021.05.024}, interhash = {1bc25c3a5caf865fe22cde02db0556e2}, intrahash = {10e9997f672c9cdb4d44afa8c5c07ab5}, journal = {Journal of Investigative Dermatology}, keywords = {Covid-19}, timestamp = {2021-10-01T14:12:28.000+0200}, title = {From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio}, url = {/brokenurl#10.1016/j.jid.2021.05.024}, year = 2021 }