Abstract
In the present study, the chalcone
(2E)-1-(3'-methoxy-4'-hydroxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one
(C16H13NO5, hereafter named AVMNB) was synthesized and structurally
characterized using the H-1 and C-13 NMR technique and GC-MS. The
vibrational and electrochemical properties of the AVMNB chalcone and its
antibacterial activity against multi-resistant strains of Escherichia
coli 06 and Staphylococcus aureus 10 were evaluated. The FT-Raman,
ATR-FTIR, and UV-VIS spectra of the polycrystalline samples were
recorded at room temperature. Quantum chemistry theoretical calculations
were used to obtain information about the normal vibration modes, and
the electronic transitions and the quantum chemical parameters expected
for this chalcone. The pharmacokinetics properties were also estimated
using the SwissADME platform. The AVMNB chalcone displayed antibacterial
activity against multiresistant strains of Staphylococcus aureus 10 and
Escherichia coli 06 when associated with the ciprofloxacin and
gentamicin antibiotics, respectively, indicating that this compound may
contribute to the control of antibacterial resistance. (C) 2020 Elsevier
B.V. All rights reserved.
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