BACKGROUND AND OBJECTIVES: We describe the first cluster of persons with Neisseria gonorrhoeae with decreased susceptibility to azithromycin (AziDS; minimum inhibitory concentration \textgreater/=1.0 microg/mL) in the United States.GOAL The goal of this study was to identify risk factors for AziDS N. gonorrhoeae and to describe isolate microbiology. STUDY DESIGN: Persons with AziDS N. gonorrhoeae (cases) were identified in Kansas City, Missouri, through the Gonococcal Isolate Surveillance Project (GISP) in 1999 and expanded surveillance, January 2000 to June 2001. A case-control study using 1999 GISP participants was conducted; control subjects had azithromycin-susceptible N. gonorrhoeae. RESULTS: Thirty-three persons with AziDS N. gonorrhoeae were identified. Case patients were older than control patients (median age, 33 years vs. 23 years; P \textless0.001). Fifty percent of cases and 13\% of control subjects had a history of sex with a female commercial sex worker (odds ratio, 7.0; 95\% confidence interval, 1.3-36.0); 50\% of cases and 4\% of control subjects met sex partners on street A (P \textless0.01). AziDS N. gonorrhoeae isolates were phenotypically and genotypically similar and contained an mtrR gene mutation. CONCLUSIONS: With few treatment options remaining, surveillance for antimicrobial-resistant N. gonorrhoeae is increasingly important, especially among persons at high risk.
%0 Journal Article
%1 mclean_emergence_2004
%A McLean, Catherine A
%A Wang, Susan A
%A Hoff, Gerald L
%A Dennis, Lesha Y
%A Trees, David L
%A Knapp, Joan S
%A Markowitz, Lauri E
%A Levine, William C
%D 2004
%J Sexually Transmitted Diseases
%K Adolescent, Adult, Aged, Agents, Azithromycin, Bacterial, Communicable Diseases, Drug Emerging, Factors, Female, Gonorrhea, Humans, Male, Microbial Middle Missouri, Neisseria Resistance, Risk Sensitivity Studies, Tests, gonorrhoeae, {Anti-Bacterial} {Case-Control} {Risk-Taking}
%N 2
%P 73--78
%R 10.1097/01.OLQ.0000109514.91508.FC
%T The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000
%U http://www.ncbi.nlm.nih.gov/pubmed/14743069
%V 31
%X BACKGROUND AND OBJECTIVES: We describe the first cluster of persons with Neisseria gonorrhoeae with decreased susceptibility to azithromycin (AziDS; minimum inhibitory concentration \textgreater/=1.0 microg/mL) in the United States.GOAL The goal of this study was to identify risk factors for AziDS N. gonorrhoeae and to describe isolate microbiology. STUDY DESIGN: Persons with AziDS N. gonorrhoeae (cases) were identified in Kansas City, Missouri, through the Gonococcal Isolate Surveillance Project (GISP) in 1999 and expanded surveillance, January 2000 to June 2001. A case-control study using 1999 GISP participants was conducted; control subjects had azithromycin-susceptible N. gonorrhoeae. RESULTS: Thirty-three persons with AziDS N. gonorrhoeae were identified. Case patients were older than control patients (median age, 33 years vs. 23 years; P \textless0.001). Fifty percent of cases and 13\% of control subjects had a history of sex with a female commercial sex worker (odds ratio, 7.0; 95\% confidence interval, 1.3-36.0); 50\% of cases and 4\% of control subjects met sex partners on street A (P \textless0.01). AziDS N. gonorrhoeae isolates were phenotypically and genotypically similar and contained an mtrR gene mutation. CONCLUSIONS: With few treatment options remaining, surveillance for antimicrobial-resistant N. gonorrhoeae is increasingly important, especially among persons at high risk.
@article{mclean_emergence_2004,
abstract = {{BACKGROUND} {AND} {OBJECTIVES:} We describe the first cluster of persons with Neisseria gonorrhoeae with decreased susceptibility to azithromycin {(AziDS;} minimum inhibitory concentration {\textgreater}/=1.0 {microg/mL)} in the United {States.GOAL} The goal of this study was to identify risk factors for {AziDS} N. gonorrhoeae and to describe isolate microbiology. {STUDY} {DESIGN:} Persons with {AziDS} N. gonorrhoeae (cases) were identified in Kansas City, Missouri, through the Gonococcal Isolate Surveillance Project {(GISP)} in 1999 and expanded surveillance, January 2000 to June 2001. A case-control study using 1999 {GISP} participants was conducted; control subjects had azithromycin-susceptible N. gonorrhoeae. {RESULTS:} Thirty-three persons with {AziDS} N. gonorrhoeae were identified. Case patients were older than control patients (median age, 33 years vs. 23 years; P {\textless}0.001). Fifty percent of cases and 13\% of control subjects had a history of sex with a female commercial sex worker (odds ratio, 7.0; 95\% confidence interval, 1.3-36.0); 50\% of cases and 4\% of control subjects met sex partners on street A {(P} {\textless}0.01). {AziDS} N. gonorrhoeae isolates were phenotypically and genotypically similar and contained an {mtrR} gene mutation. {CONCLUSIONS:} With few treatment options remaining, surveillance for antimicrobial-resistant N. gonorrhoeae is increasingly important, especially among persons at high risk.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {{McLean}, Catherine A and Wang, Susan A and Hoff, Gerald L and Dennis, Lesha Y and Trees, David L and Knapp, Joan S and Markowitz, Lauri E and Levine, William C},
biburl = {https://www.bibsonomy.org/bibtex/20d4d0e7fadb0b830d5ad9364fe790ce3/jelias},
doi = {10.1097/01.OLQ.0000109514.91508.FC},
interhash = {c738409118d77260b45779b351c009d9},
intrahash = {0d4d0e7fadb0b830d5ad9364fe790ce3},
issn = {0148-5717},
journal = {Sexually Transmitted Diseases},
keywords = {Adolescent, Adult, Aged, Agents, Azithromycin, Bacterial, Communicable Diseases, Drug Emerging, Factors, Female, Gonorrhea, Humans, Male, Microbial Middle Missouri, Neisseria Resistance, Risk Sensitivity Studies, Tests, gonorrhoeae, {Anti-Bacterial} {Case-Control} {Risk-Taking}},
month = feb,
note = {{PMID:} 14743069},
number = 2,
pages = {73--78},
timestamp = {2011-03-11T10:06:14.000+0100},
title = {The emergence of Neisseria gonorrhoeae with decreased susceptibility to Azithromycin in Kansas City, Missouri, 1999 to 2000},
url = {http://www.ncbi.nlm.nih.gov/pubmed/14743069},
volume = 31,
year = 2004
}