%0 Journal Article %1 hollingworth2011commondisease. %A Hollingworth, P %A Harold, D %A Sims, R %A Gerrish, A %A Lambert, JC %A Carrasquillo, MM %A Abraham, R %A Hamshere, ML %A Pahwa, JS %A Moskvina, V %A Dowzell, K %A Jones, N %A Stretton, A %A Thomas, C %A Richards, A %A Ivanov, D %A Widdowson, C %A Chapman, J %A Lovestone, S %A Powell, J %A Proitsi, P %A Lupton, MK %A Brayne, C %A Rubinsztein, DC %A Gill, M %A Lawlor, B %A Lynch, A %A Brown, KS %A Passmore, PA %A Craig, D %A McGuinness, B %A Todd, S %A Holmes, C %A Mann, D %A Smith, AD %A Beaumont, H %A Warden, D %A Wilcock, G %A Love, S %A Kehoe, PG %A Hooper, NM %A Vardy, ER %A Hardy, J %A Mead, S %A Fox, NC %A Rossor, M %A Collinge, J %A Maier, W %A Jessen, F %A Rüther, E %A Schürmann, B %A Heun, R %A Kölsch, H %A van den Bussche, H %A Heuser, I %A Kornhuber, J %A Wiltfang, J %A Dichgans, M %A Frölich, L %A Hampel, H %A Gallacher, J %A Hüll, M %A Rujescu, D %A Giegling, I %A Goate, AM %A Kauwe, JS %A Cruchaga, C %A Nowotny, P %A Morris, JC %A Mayo, K %A Sleegers, K %A Bettens, K %A Engelborghs, S %A De Deyn, PP %A Van Broeckhoven, C %A Livingston, G %A Bass, NJ %A Gurling, H %A McQuillin, A %A Gwilliam, R %A Deloukas, P %A Al-Chalabi, A %A Shaw, CE %A Tsolaki, M %A Singleton, AB %A Guerreiro, R %A Mühleisen, TW %A Nöthen, MM %A Moebus, S %A Jöckel, KH %A Klopp, N %A Wichmann, HE %A Pankratz, VS %A Sando, SB %A Aasly, JO %A Barcikowska, M %A Wszolek, ZK %A Dickson, DW %A Graff-Radford, NR %A Petersen, RC %A Initiative, Alzheimer's Disease Neuroimaging %A van Duijn, CM %A Breteler, MM %A Ikram, MA %A DeStefano, AL %A Fitzpatrick, AL %A Lopez, O %A Launer, LJ %A Seshadri, S %A consortium, CHARGE %A Berr, C %A Campion, D %A Epelbaum, J %A Dartigues, JF %A Tzourio, C %A Alpérovitch, A %A Lathrop, M %A consortium, EADI1 %A Feulner, TM %A Friedrich, P %A Riehle, C %A Krawczak, M %A Schreiber, S %A Mayhaus, M %A Nicolhaus, S %A Wagenpfeil, S %A Steinberg, S %A Stefansson, H %A Stefansson, K %A Snaedal, J %A Björnsson, S %A Jonsson, PV %A Chouraki, V %A Genier-Boley, B %A Hiltunen, M %A Soininen, H %A Combarros, O %A Zelenika, D %A Delepine, M %A Bullido, MJ %A Pasquier, F %A Mateo, I %A Frank-Garcia, A %A Porcellini, E %A Hanon, O %A Coto, E %A Alvarez, V %A Bosco, P %A Siciliano, G %A Mancuso, M %A Panza, F %A Solfrizzi, V %A Nacmias, B %A Sorbi, S %A Bossù, P %A Piccardi, P %A Arosio, B %A Annoni, G %A Seripa, D %A Pilotto, A %A Scarpini, E %A Galimberti, D %A Brice, A %A Hannequin, D %A Licastro, F %A Jones, L %A Holmans, PA %A Jonsson, T %A Riemenschneider, M %A Morgan, K %A Younkin, SG %A Owen, MJ %A O'Donovan, M %A Amouyel, P %A Williams, J %C Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK. %D 2011 %J Nat Genet %K imported %N 5 %P 429--435 %R 10.1038/ng.803 %T Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. %U http://www.ncbi.nlm.nih.gov/pubmed/21460840 %V 43 %X We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).

@article{hollingworth2011commondisease., abstract = {We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10(-5). We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10(-4); including ADGC data, meta P = 8.6 × 10(-9)), CD33 (GERAD+, P = 2.2 × 10(-4); including ADGC data, meta P = 1.6 × 10(-9)) and EPHA1 (GERAD+, P = 3.4 × 10(-4); including ADGC data, meta P = 6.0 × 10(-10)).}, added-at = {2013-08-12T12:53:15.000+0200}, address = {Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Neurosciences and Mental Health Research Institute, Department of Psychological Medicine and Neurology, School of Medicine, Cardiff University, Cardiff, UK.}, author = {Hollingworth, P and Harold, D and Sims, R and Gerrish, A and Lambert, JC and Carrasquillo, MM and Abraham, R and Hamshere, ML and Pahwa, JS and Moskvina, V and Dowzell, K and Jones, N and Stretton, A and Thomas, C and Richards, A and Ivanov, D and Widdowson, C and Chapman, J and Lovestone, S and Powell, J and Proitsi, P and Lupton, MK and Brayne, C and Rubinsztein, DC and Gill, M and Lawlor, B and Lynch, A and Brown, KS and Passmore, PA and Craig, D and McGuinness, B and Todd, S and Holmes, C and Mann, D and Smith, AD and Beaumont, H and Warden, D and Wilcock, G and Love, S and Kehoe, PG and Hooper, NM and Vardy, ER and Hardy, J and Mead, S and Fox, NC and Rossor, M and Collinge, J and Maier, W and Jessen, F and Rüther, E and Schürmann, B and Heun, R and Kölsch, H and van den Bussche, H and Heuser, I and Kornhuber, J and Wiltfang, J and Dichgans, M and Frölich, L and Hampel, H and Gallacher, J and Hüll, M and Rujescu, D and Giegling, I and Goate, AM and Kauwe, JS and Cruchaga, C and Nowotny, P and Morris, JC and Mayo, K and Sleegers, K and Bettens, K and Engelborghs, S and De Deyn, PP and Van Broeckhoven, C and Livingston, G and Bass, NJ and Gurling, H and McQuillin, A and Gwilliam, R and Deloukas, P and Al-Chalabi, A and Shaw, CE and Tsolaki, M and Singleton, AB and Guerreiro, R and Mühleisen, TW and Nöthen, MM and Moebus, S and Jöckel, KH and Klopp, N and Wichmann, HE and Pankratz, VS and Sando, SB and Aasly, JO and Barcikowska, M and Wszolek, ZK and Dickson, DW and Graff-Radford, NR and Petersen, RC and Initiative, Alzheimer's Disease Neuroimaging and van Duijn, CM and Breteler, MM and Ikram, MA and DeStefano, AL and Fitzpatrick, AL and Lopez, O and Launer, LJ and Seshadri, S and consortium, CHARGE and Berr, C and Campion, D and Epelbaum, J and Dartigues, JF and Tzourio, C and Alpérovitch, A and Lathrop, M and consortium, EADI1 and Feulner, TM and Friedrich, P and Riehle, C and Krawczak, M and Schreiber, S and Mayhaus, M and Nicolhaus, S and Wagenpfeil, S and Steinberg, S and Stefansson, H and Stefansson, K and Snaedal, J and Björnsson, S and Jonsson, PV and Chouraki, V and Genier-Boley, B and Hiltunen, M and Soininen, H and Combarros, O and Zelenika, D and Delepine, M and Bullido, MJ and Pasquier, F and Mateo, I and Frank-Garcia, A and Porcellini, E and Hanon, O and Coto, E and Alvarez, V and Bosco, P and Siciliano, G and Mancuso, M and Panza, F and Solfrizzi, V and Nacmias, B and Sorbi, S and Bossù, P and Piccardi, P and Arosio, B and Annoni, G and Seripa, D and Pilotto, A and Scarpini, E and Galimberti, D and Brice, A and Hannequin, D and Licastro, F and Jones, L and Holmans, PA and Jonsson, T and Riemenschneider, M and Morgan, K and Younkin, SG and Owen, MJ and O'Donovan, M and Amouyel, P and Williams, J}, biburl = {https://www.bibsonomy.org/bibtex/2373fe0ae862e14894607ae70dd03ea36/sokratesagogo}, doi = {10.1038/ng.803}, eissn = {1546-1718}, interhash = {cbee98559c660d31140afc4eda9d0097}, intrahash = {373fe0ae862e14894607ae70dd03ea36}, journal = {Nat Genet}, keyword = {ATP-Binding Cassette Transporters}, keywords = {imported}, language = {eng}, month = May, note = {PMCID: PMC3084173}, number = 5, organization = {United States}, pages = {429--435}, pii = {ng.803}, timestamp = {2013-08-12T12:53:42.000+0200}, title = {Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21460840}, volume = 43, year = 2011 }