In addition to its established role in innate immune mechanisms, complement component C3 is also of critical importance in B cell activation and T cell-dependent Ab responses. In this study, we have examined the requirement for C3 in the generation of primary CD8 T cell responses to an acute systemic viral infection. We compared Ag-specific CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) between wild-type (+/+) and C3-deficient (C3(-/-)) mice on both 129/B6 and B6 backgrounds. These studies revealed that C3 activity is required for optimal expansion of LCMV-specific effector CD8 T cells in an epitope-dependent fashion, which is influenced by the genetic background of the mice. Studies in complement receptor 1/2 (CR1/CR2)-deficient mice showed that regulation of LCMV-specific CD8 T cell responses by C3 is not dependent upon CR1/CR2. These findings may have implications in vaccine development, therapy of autoimmune diseases, and prevention of graft rejection.
%0 Journal Article
%1 Suresh:2003tj
%A Suresh, M
%A Molina, Hector
%A Salvato, Maria S
%A Mastellos, Dimitrios
%A Lambris, John D.
%A Sandor, Matyas
%D 2003
%J Journal of Immunology
%K imported
%N 2
%P 788--794
%T Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection.
%U http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12517942&retmode=ref&cmd=prlinks
%V 170
%X In addition to its established role in innate immune mechanisms, complement component C3 is also of critical importance in B cell activation and T cell-dependent Ab responses. In this study, we have examined the requirement for C3 in the generation of primary CD8 T cell responses to an acute systemic viral infection. We compared Ag-specific CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) between wild-type (+/+) and C3-deficient (C3(-/-)) mice on both 129/B6 and B6 backgrounds. These studies revealed that C3 activity is required for optimal expansion of LCMV-specific effector CD8 T cells in an epitope-dependent fashion, which is influenced by the genetic background of the mice. Studies in complement receptor 1/2 (CR1/CR2)-deficient mice showed that regulation of LCMV-specific CD8 T cell responses by C3 is not dependent upon CR1/CR2. These findings may have implications in vaccine development, therapy of autoimmune diseases, and prevention of graft rejection.
@article{Suresh:2003tj,
abstract = {In addition to its established role in innate immune mechanisms, complement component C3 is also of critical importance in B cell activation and T cell-dependent Ab responses. In this study, we have examined the requirement for C3 in the generation of primary CD8 T cell responses to an acute systemic viral infection. We compared Ag-specific CD8 T cell responses to lymphocytic choriomeningitis virus (LCMV) between wild-type (+/+) and C3-deficient (C3(-/-)) mice on both 129/B6 and B6 backgrounds. These studies revealed that C3 activity is required for optimal expansion of LCMV-specific effector CD8 T cells in an epitope-dependent fashion, which is influenced by the genetic background of the mice. Studies in complement receptor 1/2 (CR1/CR2)-deficient mice showed that regulation of LCMV-specific CD8 T cell responses by C3 is not dependent upon CR1/CR2. These findings may have implications in vaccine development, therapy of autoimmune diseases, and prevention of graft rejection.},
added-at = {2017-12-08T05:18:19.000+0100},
affiliation = {Department of Pathobiological Sciences, University of Wisconsin, Madison 53706, USA. sureshm@svm.vetmed.wisc.edu},
author = {Suresh, M and Molina, Hector and Salvato, Maria S and Mastellos, Dimitrios and Lambris, John D. and Sandor, Matyas},
biburl = {https://www.bibsonomy.org/bibtex/239666f4f0992213d1be63a42cc475ab4/lambris},
date-added = {2012-03-27T20:49:05GMT},
date-modified = {2017-12-08T04:17:04GMT},
interhash = {cc53aaa3014b77f49ab352c7c9403673},
intrahash = {39666f4f0992213d1be63a42cc475ab4},
journal = {Journal of Immunology},
keywords = {imported},
language = {English},
month = jan,
number = 2,
pages = {788--794},
pmid = {12517942},
rating = {0},
timestamp = {2017-12-08T05:18:19.000+0100},
title = {{Complement component 3 is required for optimal expansion of CD8 T cells during a systemic viral infection.}},
uri = {\url{papers3://publication/uuid/F80005DF-F7A6-49E3-AD01-41E4C9817B33}},
url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12517942&retmode=ref&cmd=prlinks},
volume = 170,
year = 2003
}