%0 Journal Article %1 RN73 %A Pessoa-Mahana, H. %A Nunez, C.U. %A Araya-Maturana, R. %A Barria, C.S. %A Zapata-Torres, G. %A Pessoa-Mahana, C.D. %A Iturriaga-Vasquez, P. %A Mella-Raipan, J. %A Reyes-Parada, M. %A Celis-Barros, C. %D 2012 %J Chemical & Pharmaceutical Bulletin %K 5-ht1a, 5-hydroxytryptamine(1a) agonists, antidepressant, arylpiperazine automated binding, derivatives, docking, dqcauchile indoles, indolylalkylarylpiperazine, inhibitors ligands, receptor, selectivity, serotonin, substituted synthesis, %N 5 %P 632-638 %R DOI 10.1248/cpb.60.632 %T Synthesis, 5-Hydroxytryptamine(1a) Receptor Affinity and Docking Studies of 3-3-(4-Aryl-1-Piperazinyl)-Propyl-1h-Indole Derivatives %U /brokenurl#<Go to ISI>://WOS:000303293000009 %V 60 %X A series of 3-3-(4-aryl-1-piperazinyl)-propyl-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine(1A) receptor (5-HT1AR) compounds (12b) and (12h) showed the highest 5-HT1A receptor affinity (IC50=15nM). Molecular docking studies with all the compounds in a homology model of 5-HT1A showed that the main interaction anchoring the ligand in the receptor was a charge-reinforced bond between the protonated nitrogen atom (N-4) of the piperazine ring and Aspartate(3.32).

@article{RN73, abstract = {A series of 3-[3-(4-aryl-1-piperazinyl)-propyl]-1H-indole derivatives (12a-h) was synthesized and evaluated for binding affinity at the human 5-hydroxytryptamine(1A) receptor (5-HT1AR) compounds (12b) and (12h) showed the highest 5-HT1A receptor affinity (IC50=15nM). Molecular docking studies with all the compounds in a homology model of 5-HT1A showed that the main interaction anchoring the ligand in the receptor was a charge-reinforced bond between the protonated nitrogen atom (N-4) of the piperazine ring and Aspartate(3.32).}, added-at = {2019-12-04T03:57:35.000+0100}, author = {Pessoa-Mahana, H. and Nunez, C.U. and Araya-Maturana, R. and Barria, C.S. and Zapata-Torres, G. and Pessoa-Mahana, C.D. and Iturriaga-Vasquez, P. and Mella-Raipan, J. and Reyes-Parada, M. and Celis-Barros, C.}, biburl = {https://www.bibsonomy.org/bibtex/25991d389a62b8ff5018af219e8b952b0/dqcauchile}, doi = {DOI 10.1248/cpb.60.632}, interhash = {dd95db288cb8e0b2b2bc59ce39c04344}, intrahash = {5991d389a62b8ff5018af219e8b952b0}, issn = {0009-2363}, journal = {Chemical & Pharmaceutical Bulletin}, keywords = {5-ht1a, 5-hydroxytryptamine(1a) agonists, antidepressant, arylpiperazine automated binding, derivatives, docking, dqcauchile indoles, indolylalkylarylpiperazine, inhibitors ligands, receptor, selectivity, serotonin, substituted synthesis,}, number = 5, pages = {632-638}, timestamp = {2019-12-04T03:58:17.000+0100}, title = {Synthesis, 5-Hydroxytryptamine(1a) Receptor Affinity and Docking Studies of 3-[3-(4-Aryl-1-Piperazinyl)-Propyl]-1h-Indole Derivatives}, type = {Journal Article}, url = {/brokenurl#<Go to ISI>://WOS:000303293000009}, volume = 60, year = 2012 }