Article,

Improving mass spectrometer sensitivity using a high-pressure electrodynamic ion funnel interface

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Journal of the American Society for Mass Spectrometry, 17 (9): 1299--1305 (September 2006)085BW Times Cited:0 Cited References Count:32.

Abstract

We report on a new electrodynamic ion funnel that operates at a pressure of 30 torr with no loss of ion transmission. The enhanced performance compared with previous ion funnel designs optimized for pressures of < 5 torr was achieved by reducing the ion funnel capacitance and increasing the RF drive frequency (1.7 MHz) and amplitude (100-170 V peak-to-peak). No degradation of ion transmission was observed for pressures from 2 to 30 torr. The ability to operate at higher pressure enabled a new tandem ion funnel mass spectrometer interface design that can accommodate a greater gas load (e.g., from an ESI source). When combined with a multicapillary inlet, the interface provided more efficient introduction of ions, resulting in a significant enhancement in mass spectrometer sensitivity and detection limits. (J Am Soc Mass Spectrom 2006, 17, 1299-1305) (c) 2006 American Society for Mass Spectrometry.

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