Neurotransmitter release is well known to occur at specialized synaptic
regions that include presynaptic active zones and postsynaptic densities.
At cholinergic synapses in the chick ciliary ganglion, however, membrane
formations and physiological measurements suggest that release distant
from postsynaptic densities can activate the predominantly extrasynaptic
alpha7 nicotinic receptor subtype. We explored such ectopic neurotransmission
with a novel model synapse that combines Monte Carlo simulations
with high-resolution serial electron microscopic tomography. Simulated
synaptic activity is consistent with experimental recordings of miniature
excitatory postsynaptic currents only when ectopic transmission is
included in the model, broadening the possibilities for mechanisms
of neuronal communication.
%0 Journal Article
%1 Cogg_2005_446
%A Coggan, Jay S
%A Bartol, Thomas M
%A Esquenazi, Eduardo
%A Stiles, Joel R
%A Lamont, Stephan
%A Martone, Maryann E
%A Berg, Darwin K
%A Ellisman, Mark H
%A Sejnowski, Terrence J
%D 2005
%J Science
%K 16020717 Acetylcholine, Acetylcholinesterase, Algorithms, Animals, Carlo Chick Computer Computer-Assisted, Diffusion, Electron, Embryo, Excitatory Extramural, Ganglia, Gov't, Image Mathematics, Membrane, Method, Microscopy, Models, Monte N.I.H., Neurological, Nicotinic, Non-P.H.S., Non-U.S. P.H.S., Parasympathetic, Patch-Clamp Postsynaptic Potentials, Probability, Processing, Receptors, Research Sensitivity Simulation, Specificity, Support, Synapses, Synaptic Techniques, Transmission, U.S. Vesicles, and s,
%N 5733
%P 446--451
%R 10.1126/science.1108239
%T Evidence for ectopic neurotransmission at a neuronal synapse.
%U http://dx.doi.org/10.1126/science.1108239
%V 309
%X Neurotransmitter release is well known to occur at specialized synaptic
regions that include presynaptic active zones and postsynaptic densities.
At cholinergic synapses in the chick ciliary ganglion, however, membrane
formations and physiological measurements suggest that release distant
from postsynaptic densities can activate the predominantly extrasynaptic
alpha7 nicotinic receptor subtype. We explored such ectopic neurotransmission
with a novel model synapse that combines Monte Carlo simulations
with high-resolution serial electron microscopic tomography. Simulated
synaptic activity is consistent with experimental recordings of miniature
excitatory postsynaptic currents only when ectopic transmission is
included in the model, broadening the possibilities for mechanisms
of neuronal communication.
@article{Cogg_2005_446,
abstract = {Neurotransmitter release is well known to occur at specialized synaptic
regions that include presynaptic active zones and postsynaptic densities.
At cholinergic synapses in the chick ciliary ganglion, however, membrane
formations and physiological measurements suggest that release distant
from postsynaptic densities can activate the predominantly extrasynaptic
alpha7 nicotinic receptor subtype. We explored such ectopic neurotransmission
with a novel model synapse that combines Monte Carlo simulations
with high-resolution serial electron microscopic tomography. Simulated
synaptic activity is consistent with experimental recordings of miniature
excitatory postsynaptic currents only when ectopic transmission is
included in the model, broadening the possibilities for mechanisms
of neuronal communication.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Coggan, Jay S and Bartol, Thomas M and Esquenazi, Eduardo and Stiles, Joel R and Lamont, Stephan and Martone, Maryann E and Berg, Darwin K and Ellisman, Mark H and Sejnowski, Terrence J},
biburl = {https://www.bibsonomy.org/bibtex/206d089a2f7616e1aa61fef6577874adb/hake},
description = {The whole bibliography file I use.},
doi = {10.1126/science.1108239},
file = {Cogg_2005_446.pdf:Cogg_2005_446.pdf:PDF},
interhash = {2a62db54ec0d80e4e58967956291eb92},
intrahash = {06d089a2f7616e1aa61fef6577874adb},
journal = {Science},
keywords = {16020717 Acetylcholine, Acetylcholinesterase, Algorithms, Animals, Carlo Chick Computer Computer-Assisted, Diffusion, Electron, Embryo, Excitatory Extramural, Ganglia, Gov't, Image Mathematics, Membrane, Method, Microscopy, Models, Monte N.I.H., Neurological, Nicotinic, Non-P.H.S., Non-U.S. P.H.S., Parasympathetic, Patch-Clamp Postsynaptic Potentials, Probability, Processing, Receptors, Research Sensitivity Simulation, Specificity, Support, Synapses, Synaptic Techniques, Transmission, U.S. Vesicles, and s,},
month = Jul,
number = 5733,
pages = {446--451},
pii = {309/5733/446},
pmid = {16020717},
timestamp = {2009-06-03T11:21:08.000+0200},
title = {Evidence for ectopic neurotransmission at a neuronal synapse.},
url = {http://dx.doi.org/10.1126/science.1108239},
volume = 309,
year = 2005
}