Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence of acute lung rejection and cytomegalovirus infection. However, the reasons for this association remain unclear. Here, we performed a longitudinal characterization of CMV-specific T-cell responses and immune activation status in the peripheral blood and bronchoalveolar lavage fluid of forty-four lung transplant patients. Acute rejection was associated with high levels of cellular activation in the periphery, reflecting strong CMV-specific CD8(+) T-cell activity post-transplant. Peripheral and lung CMV-specific CD8(+) T-cell responses were very similar, and related to the presence of CMV in the transplanted organ. These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection.
INSERM UMR S 945, Infections and Immunity, Universit?? Pierre et Marie Curie-Paris6, H??pital Piti??-Salp??tri??re, 75013 Paris, France. a.roux@hopital-foch.org
%0 Journal Article
%1 Roux2013a
%A Roux, Antoine
%A Mourin, Gis??le
%A Fastenackels, Sol??ne
%A Almeida, Jorge R.
%A Iglesias, Maria Candela
%A Boyd, Anders
%A Gostick, Emma
%A Larsen, Martin
%A Price, David A.
%A Sacre, Karim
%A Douek, Daniel C.
%A Autran, Brigitte
%A Picard, Cl??ment
%A Miranda, Sandra de
%A Sauce, Delphine
%A Stern, Marc
%A Appay, Victor
%D 2013
%J Clin Immunol
%K cmv rejection transplantation tlymphocytes facs
%N 1
%P 16--26
%R 10.1016/j.clim.2013.03.012
%T CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.
%U http://dx.doi.org/10.1016/j.clim.2013.03.012
%V 148
%X Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence of acute lung rejection and cytomegalovirus infection. However, the reasons for this association remain unclear. Here, we performed a longitudinal characterization of CMV-specific T-cell responses and immune activation status in the peripheral blood and bronchoalveolar lavage fluid of forty-four lung transplant patients. Acute rejection was associated with high levels of cellular activation in the periphery, reflecting strong CMV-specific CD8(+) T-cell activity post-transplant. Peripheral and lung CMV-specific CD8(+) T-cell responses were very similar, and related to the presence of CMV in the transplanted organ. These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection.
@article{Roux2013a,
abstract = {Lung transplantation is the definitive treatment for terminal respiratory disease, but the associated mortality rate is high. Acute rejection of the transplanted lung is a key determinant of adverse prognosis. Furthermore, an epidemiological relationship has been established between the occurrence of acute lung rejection and cytomegalovirus infection. However, the reasons for this association remain unclear. Here, we performed a longitudinal characterization of CMV-specific T-cell responses and immune activation status in the peripheral blood and bronchoalveolar lavage fluid of forty-four lung transplant patients. Acute rejection was associated with high levels of cellular activation in the periphery, reflecting strong CMV-specific CD8(+) T-cell activity post-transplant. Peripheral and lung CMV-specific CD8(+) T-cell responses were very similar, and related to the presence of CMV in the transplanted organ. These findings support that activated CMV-specific CD8(+) T-cells in the lung may play a role in promoting acute rejection.},
added-at = {2014-01-11T02:16:48.000+0100},
author = {Roux, Antoine and Mourin, Gis??le and Fastenackels, Sol??ne and Almeida, Jorge R. and Iglesias, Maria Candela and Boyd, Anders and Gostick, Emma and Larsen, Martin and Price, David A. and Sacre, Karim and Douek, Daniel C. and Autran, Brigitte and Picard, Cl??ment and Miranda, Sandra de and Sauce, Delphine and Stern, Marc and Appay, Victor},
biburl = {https://www.bibsonomy.org/bibtex/20a9cffcdf63346a5bd459405e082e15c/aorchid},
doi = {10.1016/j.clim.2013.03.012},
file = {:allorejection/ClinImmunol.148.16.pdf:PDF},
groups = {public},
institution = {INSERM UMR S 945, Infections and Immunity, Universit?? Pierre et Marie Curie-Paris6, H??pital Piti??-Salp??tri??re, 75013 Paris, France. a.roux@hopital-foch.org},
interhash = {7c816ff4019a5f2d2013051966b88316},
intrahash = {0a9cffcdf63346a5bd459405e082e15c},
journal = {Clin Immunol},
keywords = {cmv rejection transplantation tlymphocytes facs},
language = {eng},
medline-pst = {ppublish},
month = Jul,
number = 1,
pages = {16--26},
pii = {S1521-6616(13)00085-5},
pmid = {23644452},
timestamp = {2014-01-11T02:16:48.000+0100},
title = {CMV driven CD8(+) T-cell activation is associated with acute rejection in lung transplantation.},
url = {http://dx.doi.org/10.1016/j.clim.2013.03.012},
username = {aorchid},
volume = 148,
year = 2013
}