The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of Hydra, the sphere breaks its initial symmetry to form a foot-head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.
%0 Journal Article
%1 Gamba2012Critical
%A Gamba, Andrea
%A Nicodemi, Mario
%A Soriano, Jordi
%A Ott, Albrecht
%D 2012
%I American Physical Society
%J Physical Review Letters
%K cells, embryonic-development, lattice\_model critical-phenomena
%P 158103+
%R 10.1103/physrevlett.108.158103
%T Critical Behavior and Axis Defining Symmetry Breaking in Hydra Embryonic Development
%U http://dx.doi.org/10.1103/physrevlett.108.158103
%V 108
%X The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of Hydra, the sphere breaks its initial symmetry to form a foot-head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.
@article{Gamba2012Critical,
abstract = {{The formation of a hollow cellular sphere is often one of the first steps of multicellular embryonic development. In the case of Hydra, the sphere breaks its initial symmetry to form a foot-head axis. During this process a gene, ks1, is increasingly expressed in localized cell domains whose size distribution becomes scale-free at the axis-locking moment. We show that a physical model based solely on the production and exchange of ks1-promoting factors among neighboring cells robustly reproduces the scaling behavior as well as the experimentally observed spontaneous and temperature-directed symmetry breaking.}},
added-at = {2019-06-10T14:53:09.000+0200},
author = {Gamba, Andrea and Nicodemi, Mario and Soriano, Jordi and Ott, Albrecht},
biburl = {https://www.bibsonomy.org/bibtex/20c49dfb046203d339332ad69ea442baa/nonancourt},
citeulike-article-id = {11197629},
citeulike-linkout-0 = {http://dx.doi.org/10.1103/physrevlett.108.158103},
citeulike-linkout-1 = {http://link.aps.org/abstract/PRL/v108/i15/e158103},
citeulike-linkout-2 = {http://link.aps.org/pdf/PRL/v108/i15/e158103},
doi = {10.1103/physrevlett.108.158103},
interhash = {6b51e83b203ecd7cfcc989949bc4caa0},
intrahash = {0c49dfb046203d339332ad69ea442baa},
journal = {Physical Review Letters},
keywords = {cells, embryonic-development, lattice\_model critical-phenomena},
month = apr,
pages = {158103+},
posted-at = {2012-09-07 11:07:46},
priority = {2},
publisher = {American Physical Society},
timestamp = {2019-07-31T12:26:23.000+0200},
title = {Critical Behavior and Axis Defining Symmetry Breaking in \textit{Hydra} Embryonic Development},
url = {http://dx.doi.org/10.1103/physrevlett.108.158103},
volume = 108,
year = 2012
}