An intense, low-frequency tone (about 30 Hz) modulates the sensitivity
of the inner ear to high-frequency stimulation. This modulation is
correlated with the displacement of the basilar membrane. The findings
suggest that the modulation may also affect cochlear tuning. We have
investigated modulation of cochlear tuning by low-frequency sound
in the guinea pig. Applying indirect methods of measurement (narrow-band
analysis of compound action potentials and compound-action-potential
tuning curves), the results suggest a shift of the excitation pattern
along the basilar membrane towards higher-frequency areas. The shift
occurred for both scala tympani and scala vestibuli displacement
of the cochlear partition. Tuning curves, obtained from single units
in the cochlear nerve, show sensitivity loss and a tip shift towards
lower frequencies. This was also found for both scala tympani displacement
and scala vestibuli displacement. The shift of the tip of the tuning
curve towards lower frequencies corresponds to the inferred high-frequency
shift of the excitation pattern. The relationship of these phenomena
with the pathophysiology of Ménière's disease and with possible active
mechanisms in cochlear transduction is discussed.
%0 Journal Article
%1 Klis1988
%A Klis, J.F.L
%A Prijs, V.F
%A Latour, J.B
%A Smoorenburg, G.F
%D 1988
%J Hearing Research
%K Compound-action-potential Low-frequency Narrow-band Single-unit analysis; curves curves; modulation; tuning
%P 163-173
%T Modulation of cochlear tuning by low frequncy sound
%V 36
%X An intense, low-frequency tone (about 30 Hz) modulates the sensitivity
of the inner ear to high-frequency stimulation. This modulation is
correlated with the displacement of the basilar membrane. The findings
suggest that the modulation may also affect cochlear tuning. We have
investigated modulation of cochlear tuning by low-frequency sound
in the guinea pig. Applying indirect methods of measurement (narrow-band
analysis of compound action potentials and compound-action-potential
tuning curves), the results suggest a shift of the excitation pattern
along the basilar membrane towards higher-frequency areas. The shift
occurred for both scala tympani and scala vestibuli displacement
of the cochlear partition. Tuning curves, obtained from single units
in the cochlear nerve, show sensitivity loss and a tip shift towards
lower frequencies. This was also found for both scala tympani displacement
and scala vestibuli displacement. The shift of the tip of the tuning
curve towards lower frequencies corresponds to the inferred high-frequency
shift of the excitation pattern. The relationship of these phenomena
with the pathophysiology of Ménière's disease and with possible active
mechanisms in cochlear transduction is discussed.
@article{Klis1988,
abstract = {An intense, low-frequency tone (about 30 Hz) modulates the sensitivity
of the inner ear to high-frequency stimulation. This modulation is
correlated with the displacement of the basilar membrane. The findings
suggest that the modulation may also affect cochlear tuning. We have
investigated modulation of cochlear tuning by low-frequency sound
in the guinea pig. Applying indirect methods of measurement (narrow-band
analysis of compound action potentials and compound-action-potential
tuning curves), the results suggest a shift of the excitation pattern
along the basilar membrane towards higher-frequency areas. The shift
occurred for both scala tympani and scala vestibuli displacement
of the cochlear partition. Tuning curves, obtained from single units
in the cochlear nerve, show sensitivity loss and a tip shift towards
lower frequencies. This was also found for both scala tympani displacement
and scala vestibuli displacement. The shift of the tip of the tuning
curve towards lower frequencies corresponds to the inferred high-frequency
shift of the excitation pattern. The relationship of these phenomena
with the pathophysiology of Ménière's disease and with possible active
mechanisms in cochlear transduction is discussed.},
added-at = {2012-01-27T14:10:42.000+0100},
author = {Klis, J.F.L and Prijs, V.F and Latour, J.B and Smoorenburg, G.F},
biburl = {https://www.bibsonomy.org/bibtex/210a071d004540b62d12ccc9d5acffb1e/muhe},
interhash = {6bfc5799789673e1d8030741426c061b},
intrahash = {10a071d004540b62d12ccc9d5acffb1e},
journal = {Hearing Research},
keywords = {Compound-action-potential Low-frequency Narrow-band Single-unit analysis; curves curves; modulation; tuning},
owner = {Mu},
pages = {163-173},
timestamp = {2012-01-27T14:10:57.000+0100},
title = {Modulation of cochlear tuning by low frequncy sound},
volume = 36,
year = 1988
}