%0 Journal Article %1 VISSCHER20175 %A Visscher, Peter M. %A Wray, Naomi R. %A Zhang, Qian %A Sklar, Pamela %A McCarthy, Mark I. %A Brown, Matthew A. %A Yang, Jian %D 2017 %J The American Journal of Human Genetics %K GWAS polygenic_adaptation review %N 1 %P 5-22 %R https://doi.org/10.1016/j.ajhg.2017.06.005 %T 10 Years of GWAS Discovery: Biology, Function, and Translation %U https://www.sciencedirect.com/science/article/pii/S0002929717302409 %V 101 %X Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.

@article{VISSCHER20175, abstract = {Application of the experimental design of genome-wide association studies (GWASs) is now 10 years old (young), and here we review the remarkable range of discoveries it has facilitated in population and complex-trait genetics, the biology of diseases, and translation toward new therapeutics. We predict the likely discoveries in the next 10 years, when GWASs will be based on millions of samples with array data imputed to a large fully sequenced reference panel and on hundreds of thousands of samples with whole-genome sequencing data.}, added-at = {2023-07-06T01:16:02.000+0200}, author = {Visscher, Peter M. and Wray, Naomi R. and Zhang, Qian and Sklar, Pamela and McCarthy, Mark I. and Brown, Matthew A. and Yang, Jian}, biburl = {https://www.bibsonomy.org/bibtex/215c8a08e35640e0435b99722b56b9278/peter.ralph}, doi = {https://doi.org/10.1016/j.ajhg.2017.06.005}, interhash = {c512055ea713f844bfc1208e1bfc75d1}, intrahash = {15c8a08e35640e0435b99722b56b9278}, issn = {0002-9297}, journal = {The American Journal of Human Genetics}, keywords = {GWAS polygenic_adaptation review}, number = 1, pages = {5-22}, timestamp = {2023-07-06T01:16:02.000+0200}, title = {10 Years of {GWAS} Discovery: Biology, Function, and Translation}, url = {https://www.sciencedirect.com/science/article/pii/S0002929717302409}, volume = 101, year = 2017 }