%0 Journal Article %1 Hagberg1978 %A Hagberg, B. %D 1978 %J Ciba Found Symp %K Adolescent; Asphyxia Neonatorum; Birth Weight; Brain Damage, Chronic; Diseases, Metabolic; Cerebral Hemorrhage; Palsy; Child; Child, Preschool; Chromosome Aberrations; Disorders; Demography; Down Syndrome; Female; Humans; Infant; Infant, Newborn; Mental Retardation; Mutation; Pregnancy; Sweden %N 59 %P 29--51 %T Severe mental retardation in Swedish children born 1959-1970: epidemiological panorama and causative factors. %X The findings from two recent Swedish retrospective studies on severely mentally retarded children born 1959-70 are surveyed. One study concerned an average county--Uppsala--in the middle of Sweden, the other a vast northern county, V?sterbotten, with a sparse population. Figures for incidence and prevalence are given, as well as the percentage distribution of aetiological/pathogenic groups and subgroups, and the frequency of multihandicaps. Prenatal causes were apparent in about 70\% of affected children, Down syndrome being the main condition (32\%). A background of mutant genes in severe mental retardation was found significantly more often in V?sterbotten than in Uppsala (17\% and 7\% respectively). Perinatal causes were revealed in 10 and 8\% (9\% of the two series pooled together) and postnatal causes in only 3 and 1\% (2\%). Associated CNS handicaps were present in about half of the children (42\% in Uppsala and 52\% in V?sterbotten), with epilepsy in 30 and 36\%, cerebral palsy in 18\% and 19\%, and a combination of epilepsy and cerebral palsy in 8 and 16\%, respectively.

@article{Hagberg1978, abstract = {The findings from two recent Swedish retrospective studies on severely mentally retarded children born 1959-70 are surveyed. One study concerned an average county--Uppsala--in the middle of Sweden, the other a vast northern county, V?sterbotten, with a sparse population. Figures for incidence and prevalence are given, as well as the percentage distribution of aetiological/pathogenic groups and subgroups, and the frequency of multihandicaps. Prenatal causes were apparent in about 70\% of affected children, Down syndrome being the main condition (32\%). A background of mutant genes in severe mental retardation was found significantly more often in V?sterbotten than in Uppsala (17\% and 7\% respectively). Perinatal causes were revealed in 10 and 8\% (9\% of the two series pooled together) and postnatal causes in only 3 and 1\% (2\%). Associated CNS handicaps were present in about half of the children (42\% in Uppsala and 52\% in V?sterbotten), with epilepsy in 30 and 36\%, cerebral palsy in 18\% and 19\%, and a combination of epilepsy and cerebral palsy in 8 and 16\%, respectively.}, added-at = {2014-07-19T20:22:25.000+0200}, author = {Hagberg, B.}, biburl = {https://www.bibsonomy.org/bibtex/2043921bac1183628fd0c849066ec94f1/ar0berts}, groups = {public}, interhash = {21e107ec033265c0b61aafbc3b185109}, intrahash = {043921bac1183628fd0c849066ec94f1}, journal = {Ciba Found Symp}, keywords = {Adolescent; Asphyxia Neonatorum; Birth Weight; Brain Damage, Chronic; Diseases, Metabolic; Cerebral Hemorrhage; Palsy; Child; Child, Preschool; Chromosome Aberrations; Disorders; Demography; Down Syndrome; Female; Humans; Infant; Infant, Newborn; Mental Retardation; Mutation; Pregnancy; Sweden}, number = 59, pages = {29--51}, pmid = {152701}, timestamp = {2014-07-19T20:22:25.000+0200}, title = {Severe mental retardation in Swedish children born 1959-1970: epidemiological panorama and causative factors.}, username = {ar0berts}, year = 1978 }