A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry
Rapid Communications in Mass Spectrometry, 11 (16):
1813--1817 (1997)Ye894
Times Cited:61
Cited References Count:14.Abstract
The ability to effectively focus and transmit ions from relatively high pressure ion sources is a key factor that affects sensitivity and dynamic range in mass spectrometry, To improve upon the mass spectrometric sensitivity achievable with electrospray ionization sources a novel ion funnel interface has been developed and implemented with a triple quadrupole mass spectrometer, The ion funnel effectively consists of a series of ring electrodes of progressively smaller internal diameter to which RF and DC electric fields are co-applied. The electric fields create a pseudo-potential causing the collisionally damped ions to be more effectively focused and transmitted as a collimated ion beam, The ion funnel concept we describe is supported by results of SIMION simulations, ion current measurements and implementation with a mass spectrometer, Electrospray ionization mass spectra for an initial ion funnel configuration demonstrated over an order of magnitude increase in signal relative to that of the instrument operated in its standard (capillary inlet-skimmer) configuration under similar conditions, (C) 1997 John Wiley & Sons, Ltd.