OBJECTIVE: In a randomized, controlled, single-blind trial, to test the hypothesis that botulinum-A toxin (BTA) injections into the upper extremity of children with spastic hemiplegia improve upper extremity function. STUDY DESIGN: Thirty children with hemiplegia, aged 2.5 to 10 years, were randomly assigned to receive: (1) a BTA injection into 1 or more of 3 muscle groups (biceps, volar forearm muscles, adductor pollicis) plus occupational therapy or (2) occupational therapy alone. Blinded outcomes obtained at baseline and at 1, 3, and 6 months included the Quality of Upper Extremity Skills Test (QUEST), goniometry measurements, grip strength, and Ashworth scores. The caregiver completed the self-care domain of the Pediatric Evaluation of Disability Inventory. RESULTS: Twenty-nine subjects completed the study. The QUEST demonstrated a significant improvement favoring the treatment group on a 2-way analysis of variance (F = 4.69, df = 1,83; P =.039). BTA treatment was also associated with an improvement in score on the self-care domain of the Pediatric Evaluation of Disability Inventory (F = 4.68, df = 1,82; P =.04). CONCLUSIONS: This study supports the effectiveness of BTA injections to improve upper extremity function of children with hemiplegia who have at least moderate spasticity.
%0 Journal Article
%1 Fehlings2000
%A Fehlings, D.
%A Rang, M.
%A Glazier, J.
%A Steele, C.
%D 2000
%J J Pediatr
%K Analysis of Variance; Arm; Botulinum Toxin Type A; Cerebral Palsy; Chi-Square Distribution; Child; Child, Preschool; Evaluation Studies; Female; Hemiplegia; Humans; Injections, Intramuscular; Male; Neuromuscular Agents; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome
%N 3
%P 331--337
%R 10.1067/mpd.2000.108393
%T An evaluation of botulinum-A toxin injections to improve upper extremity function in children with hemiplegic cerebral palsy.
%U http://dx.doi.org/10.1067/mpd.2000.108393
%V 137
%X OBJECTIVE: In a randomized, controlled, single-blind trial, to test the hypothesis that botulinum-A toxin (BTA) injections into the upper extremity of children with spastic hemiplegia improve upper extremity function. STUDY DESIGN: Thirty children with hemiplegia, aged 2.5 to 10 years, were randomly assigned to receive: (1) a BTA injection into 1 or more of 3 muscle groups (biceps, volar forearm muscles, adductor pollicis) plus occupational therapy or (2) occupational therapy alone. Blinded outcomes obtained at baseline and at 1, 3, and 6 months included the Quality of Upper Extremity Skills Test (QUEST), goniometry measurements, grip strength, and Ashworth scores. The caregiver completed the self-care domain of the Pediatric Evaluation of Disability Inventory. RESULTS: Twenty-nine subjects completed the study. The QUEST demonstrated a significant improvement favoring the treatment group on a 2-way analysis of variance (F = 4.69, df = 1,83; P =.039). BTA treatment was also associated with an improvement in score on the self-care domain of the Pediatric Evaluation of Disability Inventory (F = 4.68, df = 1,82; P =.04). CONCLUSIONS: This study supports the effectiveness of BTA injections to improve upper extremity function of children with hemiplegia who have at least moderate spasticity.
@article{Fehlings2000,
abstract = {OBJECTIVE: In a randomized, controlled, single-blind trial, to test the hypothesis that botulinum-A toxin (BTA) injections into the upper extremity of children with spastic hemiplegia improve upper extremity function. STUDY DESIGN: Thirty children with hemiplegia, aged 2.5 to 10 years, were randomly assigned to receive: (1) a BTA injection into 1 or more of 3 muscle groups (biceps, volar forearm muscles, adductor pollicis) plus occupational therapy or (2) occupational therapy alone. Blinded outcomes obtained at baseline and at 1, 3, and 6 months included the Quality of Upper Extremity Skills Test (QUEST), goniometry measurements, grip strength, and Ashworth scores. The caregiver completed the self-care domain of the Pediatric Evaluation of Disability Inventory. RESULTS: Twenty-nine subjects completed the study. The QUEST demonstrated a significant improvement favoring the treatment group on a 2-way analysis of variance (F = 4.69, df = 1,83; P =.039). BTA treatment was also associated with an improvement in score on the self-care domain of the Pediatric Evaluation of Disability Inventory (F = 4.68, df = 1,82; P =.04). CONCLUSIONS: This study supports the effectiveness of BTA injections to improve upper extremity function of children with hemiplegia who have at least moderate spasticity.},
added-at = {2014-07-19T19:26:08.000+0200},
author = {Fehlings, D. and Rang, M. and Glazier, J. and Steele, C.},
biburl = {https://www.bibsonomy.org/bibtex/226f70ee453a2b5ab0ac8ba23d29fa8ca/ar0berts},
doi = {10.1067/mpd.2000.108393},
groups = {public},
interhash = {f3fc897ac9f3ee95830c007ec2d44603},
intrahash = {26f70ee453a2b5ab0ac8ba23d29fa8ca},
journal = {J Pediatr},
keywords = {Analysis of Variance; Arm; Botulinum Toxin Type A; Cerebral Palsy; Chi-Square Distribution; Child; Child, Preschool; Evaluation Studies; Female; Hemiplegia; Humans; Injections, Intramuscular; Male; Neuromuscular Agents; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome},
month = Sep,
number = 3,
pages = {331--337},
pii = {S0022-3476(00)18888-2},
pmid = {10969256},
timestamp = {2014-07-19T19:26:08.000+0200},
title = {An evaluation of botulinum-A toxin injections to improve upper extremity function in children with hemiplegic cerebral palsy.},
url = {http://dx.doi.org/10.1067/mpd.2000.108393},
username = {ar0berts},
volume = 137,
year = 2000
}