AIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml range, 4.9-51.9 vs 9
%0 Journal Article
%1 Duff.2005
%A Duff, S. E.
%A Saunders, M.
%A McCredie, V.
%A Kumar, S.
%A O'Dwyer, S. T.
%A Jayson, G. C.
%D 2005
%J Clin.Oncol.(R.Coll.Radiol.)
%K A Adult Aged Assay C Cohort Colorectal D Endothelial Enzyme-Linked Factor Factors Female Growth Human Humans Immunosorbent Lymphatic Male Metastasis Middle Neoplasms Studies Vascular blood diagnosis methods pathology protein
%N 5
%P 367-371
%T Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer
%U PM:16097569
%V 17
%X AIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml range, 4.9-51.9 vs 9
@article{Duff.2005,
abstract = {AIMS: Vascular endothelial growth factor (VEGF)-C and VEGF-D are angiogenic and lymphangiogenic members of the VEGF family of growth factors. Increased VEGF-C or VEGF-D expression in human tumours may be associated with lymph-node metastasis and lymphatic invasion. Circulating plasma levels of VEGF-A, VEGF-C and VEGF-D were measured in patients with colorectal cancer, and assessed for their usefulness as a diagnostic tool for determining lymph-node metastasis. MATERIALS AND METHODS: One hundred and twenty patients with colorectal cancer and 50 healthy control patients were included in the study. Plasma growth-factor levels were assessed by enzyme-linked immunosorbent assays. RESULTS: No significant differences in plasma VEGF-C or VEGF-D levels were seen between patients subgrouped by clinicopathological variables. In particular, there were no differences in median plasma VEGF-C or VEGF-D level in patients with and without lymph-node involvement (VEGF-C: 11.2 U/ml [range, 4.9-51.9] vs 9},
added-at = {2010-02-05T11:28:39.000+0100},
author = {Duff, S. E. and Saunders, M. and McCredie, V. and Kumar, S. and O'Dwyer, S. T. and Jayson, G. C.},
biburl = {https://www.bibsonomy.org/bibtex/2284adf235756fcf696d5bd2fcd64cf9a/kanefendt},
interhash = {aae2e029bb658d9c0b2ec75680ed3247},
intrahash = {284adf235756fcf696d5bd2fcd64cf9a},
journal = {Clin.Oncol.(R.Coll.Radiol.)},
keywords = {A Adult Aged Assay C Cohort Colorectal D Endothelial Enzyme-Linked Factor Factors Female Growth Human Humans Immunosorbent Lymphatic Male Metastasis Middle Neoplasms Studies Vascular blood diagnosis methods pathology protein},
number = 5,
pages = {367-371},
timestamp = {2010-02-05T11:28:42.000+0100},
title = {Pre-operative plasma levels of vascular endothelial growth factor A, C and D in patients with colorectal cancer},
url = {PM:16097569},
volume = 17,
year = 2005
}