Impact of Vitamin D Deficiency on Pregnancy
CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (5):
705-708 (September 2023)Abstract
Relevance. Recently, much attention has been paid to studying the prevalence of vitamin D insufficiency and deficiency in the population. The steps involved in the biological effects of vitamin D are being studied extensively. It should be recognized that this disorder is of interest to both obstetrician-gynecologists and other specialists, since vitamin D deficiency is associated with oncological, neurological, cardiovascular and autoimmune diseases, as well as various pathologies in the field of obstetrics and gynecology. Recently, there has been a sharp increase in interest in the "hormone D" - calcitriol and its receptors (VDR) as risk factors for the development of a number of obstetric complications. Vitamin D receptors have been found in the ovaries, uterus, placenta, and pituitary gland. According to some studies, vitamin D deficiency during pregnancy increases the risk of preterm birth. It is involved in the processes of angiogenesis, inhibition of cell proliferation, maintains genetic homeostasis and final differentiation of fetuses, affects the production of macrophages, the functioning of the pancreas, and the reninangiotensin system (1, 16,31).