%0 Journal Article %1 Engel.2007 %A Engel, Christoph %A Brunkhorst, Frank M. %A Bone, Hans-Georg %A Brunkhorst, Reinhard %A Gerlach, Herwig %A Grond, Stefan %A Gruendling, Matthias %A Huhle, Guenter %A Jaschinski, Ulrich %A John, Stefan %A Mayer, Konstantin %A Oppert, Michael %A Olthoff, Derk %A Quintel, Michael %A Ragaller, Max %A Rossaint, Rolf %A Stuber, Frank %A Weiler, Norbert %A Welte, Tobias %A Bogatsch, Holger %A Hartog, Christiane %A Loeffler, Markus %A Reinhart, Konrad %D 2007 %J Intensive care medicine %K IMISE-Publikationen %N 4 %P 606–618 %T Epidemiology of sepsis in Germany: results from a national prospective multicenter study %V 33 %X OBJECTIVE To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size. DESIGN Prospective, observational, cross-sectional 1-day point-prevalence study. SETTING 454 ICUs from a representative nationwide sample of 310 hospitals stratified by size. Data were collected via 1-day on-site audits by trained external study physicians. Visits were randomly distributed over 1 year (2003). PATIENTS Inflammatory response of all ICU patients was assessed using the ACCP/SCCM consensus conference criteria. Patients with severe sepsis were followed up after 3 months for hospital mortality and length of ICU stay. MEASUREMENTS AND RESULTS Main outcome measures were prevalence and mortality. A total of 3,877 patients were screened. Prevalence was 12.4\% (95\% CI, 10.9-13.8\%) for sepsis and 11.0\% (95\% CI, 9.7-12.2\%) for severe sepsis including septic shock. The ICU and hospital mortality of patients with severe sepsis was 48.4 and 55.2\%, respectively, without significant differences between hospital size. Prevalence and mean length of ICU stay of patients with severe sepsis were significantly higher in larger hospitals and universities (</= 200 beds: 6\% and 11.5 days, universities: 19\% and 19.2 days, respectively). CONCLUSIONS The expected number of newly diagnosed cases with severe sepsis in Germany amounts to 76-110 per 100,000 adult inhabitants. To allow better comparison between countries, future epidemiological studies should use standardized study methodologies with respect to sepsis definitions, hospital size, and daily and monthly variability.

@article{Engel.2007, abstract = {OBJECTIVE To determine the prevalence and mortality of ICU patients with severe sepsis in Germany, with consideration of hospital size. DESIGN Prospective, observational, cross-sectional 1-day point-prevalence study. SETTING 454 ICUs from a representative nationwide sample of 310 hospitals stratified by size. Data were collected via 1-day on-site audits by trained external study physicians. Visits were randomly distributed over 1 year (2003). PATIENTS Inflammatory response of all ICU patients was assessed using the ACCP/SCCM consensus conference criteria. Patients with severe sepsis were followed up after 3 months for hospital mortality and length of ICU stay. MEASUREMENTS AND RESULTS Main outcome measures were prevalence and mortality. A total of 3,877 patients were screened. Prevalence was 12.4\% (95\% CI, 10.9-13.8\%) for sepsis and 11.0\% (95\% CI, 9.7-12.2\%) for severe sepsis including septic shock. The ICU and hospital mortality of patients with severe sepsis was 48.4 and 55.2\%, respectively, without significant differences between hospital size. Prevalence and mean length of ICU stay of patients with severe sepsis were significantly higher in larger hospitals and universities (</= 200 beds: 6\% and 11.5 days, universities: 19\% and 19.2 days, respectively). CONCLUSIONS The expected number of newly diagnosed cases with severe sepsis in Germany amounts to 76-110 per 100,000 adult inhabitants. To allow better comparison between countries, future epidemiological studies should use standardized study methodologies with respect to sepsis definitions, hospital size, and daily and monthly variability.}, added-at = {2014-10-15T15:03:44.000+0200}, author = {Engel, Christoph and Brunkhorst, Frank M. and Bone, Hans-Georg and Brunkhorst, Reinhard and Gerlach, Herwig and Grond, Stefan and Gruendling, Matthias and Huhle, Guenter and Jaschinski, Ulrich and John, Stefan and Mayer, Konstantin and Oppert, Michael and Olthoff, Derk and Quintel, Michael and Ragaller, Max and Rossaint, Rolf and Stuber, Frank and Weiler, Norbert and Welte, Tobias and Bogatsch, Holger and Hartog, Christiane and Loeffler, Markus and Reinhart, Konrad}, biburl = {https://www.bibsonomy.org/bibtex/22de8ded78140f5dc15b5f79d694b5113/drtester}, interhash = {f7f129c48dd167109209930f1935c0a8}, intrahash = {2de8ded78140f5dc15b5f79d694b5113}, journal = {Intensive care medicine}, keywords = {IMISE-Publikationen}, number = 4, pages = {606–618}, timestamp = {2014-12-03T00:08:22.000+0100}, title = {Epidemiology of sepsis in Germany: results from a national prospective multicenter study}, volume = 33, year = 2007 }