%0 Journal Article %1 Watson1986discrete %A Watson, M R %D 1986 %J Comput Appl Biosci %K classic flux-analysis %N 1 %P 23-27 %T A discrete model of bacterial metabolism %U https://www.ncbi.nlm.nih.gov/pubmed/3450354 %V 2 %X This paper describes a computer model of the intermediary metabolism of bacteria during steady-state growth and during adaptations, e.g. to new carbon sources. Metabolic regulation is represented as a process of optimisation, in which the trend is towards improved metabolic performance. The model uses linear programming techniques for the optimisation. The implementation falls into four phases: (i) assembly of model parameters; (ii) calculations; (iii) storage of solutions and (iv) projection of solutions. The use of a commercial database and a commercial spreadsheet has proved to be of great assistance in the first and third phases. A metabolic map format, with the optional addition of conversion values, names of enzymes or co-factors has been used to project the results in a form convenient for inspection.

@article{Watson1986discrete, abstract = {This paper describes a computer model of the intermediary metabolism of bacteria during steady-state growth and during adaptations, e.g. to new carbon sources. Metabolic regulation is represented as a process of optimisation, in which the trend is towards improved metabolic performance. The model uses linear programming techniques for the optimisation. The implementation falls into four phases: (i) assembly of model parameters; (ii) calculations; (iii) storage of solutions and (iv) projection of solutions. The use of a commercial database and a commercial spreadsheet has proved to be of great assistance in the first and third phases. A metabolic map format, with the optional addition of conversion values, names of enzymes or co-factors has been used to project the results in a form convenient for inspection.}, added-at = {2019-03-19T14:16:04.000+0100}, author = {Watson, M R}, biburl = {https://www.bibsonomy.org/bibtex/231713eac41acf497f30323c27638f575/karthikraman}, description = {A discrete model of bacterial metabolism. - PubMed - NCBI}, interhash = {bb74b42b8915f4fcb7daf183830cd55a}, intrahash = {31713eac41acf497f30323c27638f575}, journal = {Comput Appl Biosci}, keywords = {classic flux-analysis}, month = apr, number = 1, pages = {23-27}, pmid = {3450354}, timestamp = {2019-03-19T14:16:04.000+0100}, title = {A discrete model of bacterial metabolism}, url = {https://www.ncbi.nlm.nih.gov/pubmed/3450354}, volume = 2, year = 1986 }