Following injury, bone has the ability to regenerate itself to a form
and function nearly indistinguishable from the pre-injury state.
However, if the injury is beyond a critical limit, recovery will
not occur without therapeutic interventions. Autografts and implants
with banked bone continue as the treatments of choice, although each
exhibits limitations and liabilities. Alternatives have included
the utilization of bone-graft substitutes that may incorporate bone
derivatives and soluble signaling molecules such as mitogens and
morphogens. In addition, an evolving treatment modality, gene therapy,
offers an exciting avenue for bone regeneration. This review presents
some of the current concepts for developing a rational gene therapy
approach in bone regeneration.
%0 Journal Article
%1 Winn2000
%A Winn, S. R.
%A Hu, Y.
%A Sfeir, C.
%A Hollinger, J. O.
%D 2000
%J Adv Drug Deliv Rev
%K *Bone *Gene ; Animals Bone Bone/therapy Cytokines/therapeutic Fractures, Gene Genetic Humans Morphogenetic Proteins/therapeutic Regeneration Targeting Therapy Vectors use
%N 1-2
%P 121-38
%T Gene therapy approaches for modulating bone regeneration.
%U http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?cmd=prlinks&dbfrom=pubmed&retmode=ref&id=10942818
%V 42
%X Following injury, bone has the ability to regenerate itself to a form
and function nearly indistinguishable from the pre-injury state.
However, if the injury is beyond a critical limit, recovery will
not occur without therapeutic interventions. Autografts and implants
with banked bone continue as the treatments of choice, although each
exhibits limitations and liabilities. Alternatives have included
the utilization of bone-graft substitutes that may incorporate bone
derivatives and soluble signaling molecules such as mitogens and
morphogens. In addition, an evolving treatment modality, gene therapy,
offers an exciting avenue for bone regeneration. This review presents
some of the current concepts for developing a rational gene therapy
approach in bone regeneration.
@article{Winn2000,
__markedentry = {[phpts:6]},
abstract = {Following injury, bone has the ability to regenerate itself to a form
and function nearly indistinguishable from the pre-injury state.
However, if the injury is beyond a critical limit, recovery will
not occur without therapeutic interventions. Autografts and implants
with banked bone continue as the treatments of choice, although each
exhibits limitations and liabilities. Alternatives have included
the utilization of bone-graft substitutes that may incorporate bone
derivatives and soluble signaling molecules such as mitogens and
morphogens. In addition, an evolving treatment modality, gene therapy,
offers an exciting avenue for bone regeneration. This review presents
some of the current concepts for developing a rational gene therapy
approach in bone regeneration.},
added-at = {2011-11-04T13:47:04.000+0100},
author = {Winn, S. R. and Hu, Y. and Sfeir, C. and Hollinger, J. O.},
authoraddress = {Department of Surgery, School of Medicine, Oregon Health Sciences
University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA.
winns@ohsu.edu},
biburl = {https://www.bibsonomy.org/bibtex/2322e5861f82599ae61c0d05aefa27470/pawelsikorski},
interhash = {8bdb320ef11bb3675858290f5be5d467},
intrahash = {322e5861f82599ae61c0d05aefa27470},
journal = {Adv Drug Deliv Rev},
keywords = {*Bone *Gene ; Animals Bone Bone/therapy Cytokines/therapeutic Fractures, Gene Genetic Humans Morphogenetic Proteins/therapeutic Regeneration Targeting Therapy Vectors use},
language = {eng},
medline-aid = {S0169-409X(00)00057-0 [pii]},
medline-da = {20000925},
medline-dcom = {20000925},
medline-edat = {2000/08/16 11:00},
medline-fau = {Winn, S R ; Hu, Y ; Sfeir, C ; Hollinger, J O},
medline-is = {0169-409X (Print)},
medline-jid = {8710523},
medline-jt = {Advanced drug delivery reviews.},
medline-lr = {20060421},
medline-mhda = {2000/09/30 11:01},
medline-own = {NLM},
medline-pl = {NETHERLANDS},
medline-pmid = {10942818},
medline-pst = {ppublish},
medline-pt = {Journal Article ; Review},
medline-pubm = {Print},
medline-rf = {173},
medline-rn = {0 (Bone Morphogenetic Proteins) ; 0 (Cytokines)},
medline-sb = {IM},
medline-so = {Adv Drug Deliv Rev. 2000 Aug 20;42(1-2):121-38.},
medline-stat = {MEDLINE},
number = {1-2},
owner = {phpts},
pages = {121-38},
timestamp = {2011-11-04T13:47:27.000+0100},
title = {Gene therapy approaches for modulating bone regeneration.},
url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?cmd=prlinks\&dbfrom=pubmed\&retmode=ref\&id=10942818},
volume = 42,
year = 2000
}