Gene expression is a fundamentally stochastic process, with randomness in transcription and
translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears
in organisms ranging from microbes to metazoans, and its characteristics depend both on the
biophysical parameters governing gene expression and on gene network structure. Stochastic gene
expression has important consequences for cellular function, being beneficial in some contexts
and harmful in others. These situations include the stress response, metabolism, development,
the cell cycle, circadian rhythms, and aging.
%0 Journal Article
%1 raj2008nnoc
%A Raj, A.
%A van Oudenaarden, A.
%D 2008
%I Elsevier
%J Cell
%K regulation review stochastic_transcription transcription
%N 2
%P 216--226
%T Nature, nurture, or chance: stochastic gene expression and its consequences
%V 135
%X Gene expression is a fundamentally stochastic process, with randomness in transcription and
translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears
in organisms ranging from microbes to metazoans, and its characteristics depend both on the
biophysical parameters governing gene expression and on gene network structure. Stochastic gene
expression has important consequences for cellular function, being beneficial in some contexts
and harmful in others. These situations include the stress response, metabolism, development,
the cell cycle, circadian rhythms, and aging.
@article{raj2008nnoc,
abstract = {Gene expression is a fundamentally stochastic process, with randomness in transcription and
translation leading to cell-to-cell variations in mRNA and protein levels. This variation appears
in organisms ranging from microbes to metazoans, and its characteristics depend both on the
biophysical parameters governing gene expression and on gene network structure. Stochastic gene
expression has important consequences for cellular function, being beneficial in some contexts
and harmful in others. These situations include the stress response, metabolism, development,
the cell cycle, circadian rhythms, and aging.
},
added-at = {2010-07-21T22:31:34.000+0200},
author = {Raj, A. and {van Oudenaarden}, A.},
biburl = {https://www.bibsonomy.org/bibtex/23328343571931ad09f5795856274f243/peter.ralph},
interhash = {338d2799ff01915692536726940c9a83},
intrahash = {3328343571931ad09f5795856274f243},
journal = {Cell},
keywords = {regulation review stochastic_transcription transcription},
number = 2,
pages = {216--226},
publisher = {Elsevier},
timestamp = {2010-07-21T22:31:34.000+0200},
title = {Nature, nurture, or chance: stochastic gene expression and its consequences},
volume = 135,
year = 2008
}