Clindamycin in Treatment of Lung Abscess in Children
M. Rahman. American Journal of Drug Delivery and Therapeutics, 1 (1):
01-08(2014)
Abstract
Abstract
Background and aims
Children with a lung abscess usually do well with antibiotics alone and
surgical intervention is rarely needed. Standard practice is to use parenteral
antibiotics until clinical symptoms abate and to follow with oral antibiotics
for up to six weeks. The objective of this study was to observe and compare
outcome, duration of antimicrobial treatment for lung abscess.
Methods
A prospective open, randomized clinical trial was conducted among 30
children aged 5 to 15 years with lung abscess and sequential antibiotic
therapy either clindamycin (group 1; n=15) or ceftriaxone, flucloxacillin plus
metronidazole (group 2; n =15) were administered until complete resolution
of clinical and radiological abnormalities.
Results
Mean age was 11.5 years in group 1 and 11 years in group 2. Blood culture
was negative in all cases but in sputum 33% cases staphylococcus aureus and
20% cases streptococcus pneumoniae was found and was sensitive to
clindamycin, flucloxacillin and ceftriaxone. ESR exceeded 20 mm/hour in
94% and CRP exceeded 20 mg/L in 95% of the cases. ESR became normal in
21 days and CRP in 10 days and the cavity size on chest radiography was
reduced after 14 days of treatment in first group but in second group CRP in
15 days, ESR in 28 days and reduced cavity size in 28 days. Mean duration
of therapy was 21 days for first group and 39 days in second group. There
were significant differences between the duration of treatment and outcome
of the two groups (P<0.05.
Conclusions
Clindamycin appears to be effective short course treatment option in lung
abscess
%0 Journal Article
%1 rahman2014clindamycin
%A Rahman, Md Atiar
%D 2014
%J American Journal of Drug Delivery and Therapeutics
%K myown
%N 1
%P 01-08
%T Clindamycin in Treatment of Lung Abscess in Children
%U https://www.primescholars.com/articles/clindamycin-in-treatment-of-lung-abscess-inchildren.pdf
%V 1
%X Abstract
Background and aims
Children with a lung abscess usually do well with antibiotics alone and
surgical intervention is rarely needed. Standard practice is to use parenteral
antibiotics until clinical symptoms abate and to follow with oral antibiotics
for up to six weeks. The objective of this study was to observe and compare
outcome, duration of antimicrobial treatment for lung abscess.
Methods
A prospective open, randomized clinical trial was conducted among 30
children aged 5 to 15 years with lung abscess and sequential antibiotic
therapy either clindamycin (group 1; n=15) or ceftriaxone, flucloxacillin plus
metronidazole (group 2; n =15) were administered until complete resolution
of clinical and radiological abnormalities.
Results
Mean age was 11.5 years in group 1 and 11 years in group 2. Blood culture
was negative in all cases but in sputum 33% cases staphylococcus aureus and
20% cases streptococcus pneumoniae was found and was sensitive to
clindamycin, flucloxacillin and ceftriaxone. ESR exceeded 20 mm/hour in
94% and CRP exceeded 20 mg/L in 95% of the cases. ESR became normal in
21 days and CRP in 10 days and the cavity size on chest radiography was
reduced after 14 days of treatment in first group but in second group CRP in
15 days, ESR in 28 days and reduced cavity size in 28 days. Mean duration
of therapy was 21 days for first group and 39 days in second group. There
were significant differences between the duration of treatment and outcome
of the two groups (P<0.05.
Conclusions
Clindamycin appears to be effective short course treatment option in lung
abscess
@article{rahman2014clindamycin,
abstract = {Abstract
Background and aims
Children with a lung abscess usually do well with antibiotics alone and
surgical intervention is rarely needed. Standard practice is to use parenteral
antibiotics until clinical symptoms abate and to follow with oral antibiotics
for up to six weeks. The objective of this study was to observe and compare
outcome, duration of antimicrobial treatment for lung abscess.
Methods
A prospective open, randomized clinical trial was conducted among 30
children aged 5 to 15 years with lung abscess and sequential antibiotic
therapy either clindamycin (group 1; n=15) or ceftriaxone, flucloxacillin plus
metronidazole (group 2; n =15) were administered until complete resolution
of clinical and radiological abnormalities.
Results
Mean age was 11.5 years in group 1 and 11 years in group 2. Blood culture
was negative in all cases but in sputum 33% cases staphylococcus aureus and
20% cases streptococcus pneumoniae was found and was sensitive to
clindamycin, flucloxacillin and ceftriaxone. ESR exceeded 20 mm/hour in
94% and CRP exceeded 20 mg/L in 95% of the cases. ESR became normal in
21 days and CRP in 10 days and the cavity size on chest radiography was
reduced after 14 days of treatment in first group but in second group CRP in
15 days, ESR in 28 days and reduced cavity size in 28 days. Mean duration
of therapy was 21 days for first group and 39 days in second group. There
were significant differences between the duration of treatment and outcome
of the two groups (P<0.05.
Conclusions
Clindamycin appears to be effective short course treatment option in lung
abscess},
added-at = {2024-05-20T12:50:36.000+0200},
author = {Rahman, Md Atiar},
biburl = {https://www.bibsonomy.org/bibtex/2353f46cb906c2b27deb7b4488fb08f17/american_jou1},
interhash = {66df4ca21a860f6765d5a56992b9c6b1},
intrahash = {353f46cb906c2b27deb7b4488fb08f17},
journal = {American Journal of Drug Delivery and Therapeutics},
keywords = {myown},
language = {English},
number = 1,
pages = {01-08},
subjectarea = {Drug Delivery},
timestamp = {2024-05-20T12:50:36.000+0200},
title = {Clindamycin in Treatment of Lung Abscess in Children
},
url = {https://www.primescholars.com/articles/clindamycin-in-treatment-of-lung-abscess-inchildren.pdf},
volume = 1,
year = 2014
}