%0 Journal Article %1 McLaughlin2002 %A McLaughlin, John %A Bjornson, Kristie %A Temkin, Nancy %A Steinbok, Paul %A Wright, Virginia %A Reiner, Ann %A Roberts, Theodore %A Drake, James %A O'Donnell, Maureen %A Rosenbaum, Peter %A Barber, Jason %A Ferrel, Anne %D 2002 %J Dev Med Child Neurol %K Cerebral Palsy; Child; Child, Preschool; Disabled Children; Female; Ganglia, Spinal; Humans; Male; Motor Skills; Randomized Controlled Trials; Rhizotomy; Treatment Outcome %N 1 %P 17--25 %T Selective dorsal rhizotomy: meta-analysis of three randomized controlled trials. %V 44 %X This study is a comparative analysis and meta-analysis of three randomized clinical trials. Children with spastic diplegia received either 'selective' dorsal rhizotomy (SDR) plus physiotherapy (SDR+PT) or PT without SDR (PT-only). Common outcome measures were used for spasticity (Ashworth scale) and function (Gross Motor Function Measure GMFM). Baseline and 9- to 12-month outcome data were pooled (n=90). At baseline, 82 children were under 8 years old and 65 had Gross Motor Function Classification System level II or III disability. Pooled Ashworth data analysis confirmed a reduction of spasticity with SDR+PT (mean change score difference -1.2; Wilcoxonp<0.001). Pooled GMFM data revealed greater functional improvement with SDR+PT (difference in change score +4.0, p=0.008). Multivariate analysis in the SDR+PT group revealed a direct relationship between percentage of dorsal root tissue transected and functional improvement. SDR+PT is efficacious in reducing spasticity in children with spastic diplegia and has a small positive effect on gross motor function.

@article{McLaughlin2002, abstract = {This study is a comparative analysis and meta-analysis of three randomized clinical trials. Children with spastic diplegia received either 'selective' dorsal rhizotomy (SDR) plus physiotherapy (SDR+PT) or PT without SDR (PT-only). Common outcome measures were used for spasticity (Ashworth scale) and function (Gross Motor Function Measure [GMFM]). Baseline and 9- to 12-month outcome data were pooled (n=90). At baseline, 82 children were under 8 years old and 65 had Gross Motor Function Classification System level II or III disability. Pooled Ashworth data analysis confirmed a reduction of spasticity with SDR+PT (mean change score difference -1.2; Wilcoxonp<0.001). Pooled GMFM data revealed greater functional improvement with SDR+PT (difference in change score +4.0, p=0.008). Multivariate analysis in the SDR+PT group revealed a direct relationship between percentage of dorsal root tissue transected and functional improvement. SDR+PT is efficacious in reducing spasticity in children with spastic diplegia and has a small positive effect on gross motor function.}, added-at = {2014-07-19T20:46:50.000+0200}, author = {McLaughlin, John and Bjornson, Kristie and Temkin, Nancy and Steinbok, Paul and Wright, Virginia and Reiner, Ann and Roberts, Theodore and Drake, James and O'Donnell, Maureen and Rosenbaum, Peter and Barber, Jason and Ferrel, Anne}, biburl = {https://www.bibsonomy.org/bibtex/238cbdcef9011369ea252c0832be3c1f4/ar0berts}, groups = {public}, interhash = {d709d7d0bee70840358ec6a905784555}, intrahash = {38cbdcef9011369ea252c0832be3c1f4}, journal = {Dev Med Child Neurol}, keywords = {Cerebral Palsy; Child; Child, Preschool; Disabled Children; Female; Ganglia, Spinal; Humans; Male; Motor Skills; Randomized Controlled Trials; Rhizotomy; Treatment Outcome}, month = Jan, number = 1, pages = {17--25}, pmid = {11811645}, timestamp = {2014-07-19T20:46:50.000+0200}, title = {Selective dorsal rhizotomy: meta-analysis of three randomized controlled trials.}, username = {ar0berts}, volume = 44, year = 2002 }