%0 Book Section %1 Suba_2019 %A Suba, Zsuzsanna %B Crosstalk in Biological Processes Working Title %D 2019 %I IntechOpen %K myown %R 10.5772/intechopen.85995 %T Crossroad between Obesity and Cancer: A Defective Signaling Function of Heavily Lipid-Laden Adipocytes %U https://doi.org/10.5772%2Fintechopen.85995 %X Abstract Obesity and its comorbidities exhibit a gender-related dimorphism. Obese males tend to accrue more visceral fat leading to abdominal adiposity, which shows a strong correlation with serious obesity-associated comorbidities, cardiovascular diseases and cancers. In contrast, obese females accumulate excessive fatty tissue predominantly subcutaneously enjoying strong protection from the obesity-related diseases. The health advantage of obese women as compared with obese men may be attributed to their higher estrogen production and an increased transactivation of estrogen receptors (ERs). The recently clarified intracrine, paracrine, and endocrine functions of adipose tissue illuminate that concentrations of estrogens and the suitable expression and activity of ERs strongly define all regulatory functions in both men and women. All well-known cancer risk factors are in correlation with defects of estrogen signaling in partnership with glucose intolerance as estrogen regulates all steps of glucose uptake. In central obesity, increased secretions of cytokines and growth factors are not causal factors of developing insulin resistance, and unrestrained cell proliferation, but rather, they are compensatory processes so as to increase estrogen synthesis and ER transactivation. In conclusion, a causal therapy against obesity and obesity-related diseases aims to improve estrogen signaling in both men and women.

@incollection{Suba_2019, abstract = { Abstract Obesity and its comorbidities exhibit a gender-related dimorphism. Obese males tend to accrue more visceral fat leading to abdominal adiposity, which shows a strong correlation with serious obesity-associated comorbidities, cardiovascular diseases and cancers. In contrast, obese females accumulate excessive fatty tissue predominantly subcutaneously enjoying strong protection from the obesity-related diseases. The health advantage of obese women as compared with obese men may be attributed to their higher estrogen production and an increased transactivation of estrogen receptors (ERs). The recently clarified intracrine, paracrine, and endocrine functions of adipose tissue illuminate that concentrations of estrogens and the suitable expression and activity of ERs strongly define all regulatory functions in both men and women. All well-known cancer risk factors are in correlation with defects of estrogen signaling in partnership with glucose intolerance as estrogen regulates all steps of glucose uptake. In central obesity, increased secretions of cytokines and growth factors are not causal factors of developing insulin resistance, and unrestrained cell proliferation, but rather, they are compensatory processes so as to increase estrogen synthesis and ER transactivation. In conclusion, a causal therapy against obesity and obesity-related diseases aims to improve estrogen signaling in both men and women.}, added-at = {2019-05-25T16:37:40.000+0200}, author = {Suba, Zsuzsanna}, biburl = {https://www.bibsonomy.org/bibtex/239c7bef0ed256aad10b772eee0f277c8/abus}, booktitle = {Crosstalk in Biological Processes [Working Title]}, doi = {10.5772/intechopen.85995}, interhash = {1ff8c446c7d100a9c73e99e0b78fa0bb}, intrahash = {39c7bef0ed256aad10b772eee0f277c8}, keywords = {myown}, language = {english}, month = may, publisher = {{IntechOpen}}, timestamp = {2019-05-25T16:37:40.000+0200}, title = {Crossroad between Obesity and Cancer: A Defective Signaling Function of Heavily Lipid-Laden Adipocytes}, type = {perspective}, url = {https://doi.org/10.5772%2Fintechopen.85995}, year = 2019 }