Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds
INTERNATIONAL JOURNAL OF TREND IN SCIENTIFIC RESEARCH AND DEVELOPMENT, 6 (5):
1653-1657 (August 2022)Abstract
The reaction of phenyl hydrazine with ethyl acetoacetate gave 3 methyl 1 phenyl 5 pyrazolone 1 , which then treated with malonitrile and benzaldehyde to give 6 amino 3 methyl 1,4 dihydropyrano 2,3 b pyrazole 5 carbonitrile 2 which considered assynthone for prepare some new pyrazole derivatives 3a j .The structure of the prepared compounds was suggested in the IR , 1 H NMR, 13 C NMR and UV Spectroscopy. Many steps starting from esterification of isophthalic acid to yield diester compound I which was converted to their acid hydrazide II , then the later compound reacted with ethylacetoacetate to yield pyrazol 5 one compound III . Afterword added acetyl chloride to give the compound IV , there action of this compound with theiosemicarbazide ledto produce a new carbothioamide compound V , Which was reacted with ethyl chloro acetate to yield thethioxoimidazolidin compound VI . The condensation reaction of this compound with different substituted aldehyde give new alkene derivatives VII a d. The synthesized compounds were characterized by melting points , FT IR ,1H NMR and Mass spectroscopy. Munesh Sharma "Synthesis and Characterization of Some Pyrazole Based Heterocyclic Compounds" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-5 , August 2022, URL: https://www.ijtsrd.com/papers/ijtsrd51723.pdf Paper URL: https://www.ijtsrd.com/chemistry/other/51723/synthesis-and-characterization-of-some-pyrazole-based-heterocyclic-compounds/munesh-sharma