Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis
Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.
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%0 Journal Article
%1 taha_circumvention_2001
%A Taha, M K
%A Bichier, E
%A Perrocheau, A
%A Alonso, J M
%D 2001
%J Infection and Immunity
%K Analysis, Chain Data, Disease Epidemiology, France, Humans, Infections, Meningococcal Molecular Molecular, Mutation, Neisseria Outbreaks, Polymerase Porins, Reaction, Sequence Vaccines, meningitidis, {DNA}
%N 3
%P 1971--1973
%R 10.1128/IAI.69.3.1971-1973.2001
%T Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the porA gene of Neisseria meningitidis
%U http://www.ncbi.nlm.nih.gov/pubmed/11179386
%V 69
%X Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.
@article{taha_circumvention_2001,
abstract = {Meningococcal strains isolated during an outbreak were shown to belong to the {ET-5} complex and to harbor a mutation in the {VR2} region of the {porA} gene. They were less susceptible to the bactericidal effect of normal human serum than was the {ET-5} wild-type strain. These results are of concern, as {PorA} is a potential target in vaccine design.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Taha, M K and Bichier, E and Perrocheau, A and Alonso, J M},
biburl = {https://www.bibsonomy.org/bibtex/20d0d65c1c617415165a82986662809f8/jelias},
doi = {10.1128/IAI.69.3.1971-1973.2001},
interhash = {23b7493ebef7e7a4fddf7ec7c70aabc6},
intrahash = {0d0d65c1c617415165a82986662809f8},
issn = {0019-9567},
journal = {Infection and Immunity},
keywords = {Analysis, Chain Data, Disease Epidemiology, France, Humans, Infections, Meningococcal Molecular Molecular, Mutation, Neisseria Outbreaks, Polymerase Porins, Reaction, Sequence Vaccines, meningitidis, {DNA}},
month = mar,
note = {{PMID:} 11179386},
number = 3,
pages = {1971--1973},
timestamp = {2011-03-11T10:06:15.000+0100},
title = {Circumvention of herd immunity during an outbreak of meningococcal disease could be correlated to escape mutation in the {porA} gene of Neisseria meningitidis},
url = {http://www.ncbi.nlm.nih.gov/pubmed/11179386},
volume = 69,
year = 2001
}