%0 Journal Article %1 Ho1995 %A Ho, N. K. %A Lim, S. B. %D 1995 %J Singapore Med J %K Birth Weight; Brain; Brain Diseases; Bronchopulmonary Dysplasia; Cause of Death; Cerebral Hemorrhage; Palsy; Child Development; Developing Countries; Disabled Persons; Humans; Infant; Infant, Low Newborn; Patient Discharge; Prognosis; Pulmonary Su; Retinopathy Prematurity; Risk Factors; Singapore; Survival Rate; rfactants %N 2 %P 185--188 %T Outcome of infants weighing 500-999 grams at birth in a Singapore hospital (1990-1993). %V 36 %X Over a 4-year period (1990-1993) 126 babies weighing 500-999 grams (0.39\% of 32,362 livebirths) were born in the hospital that provides tertiary care. Seventy-eight babies (61.9\%) were discharged alive. Survival rate (79.4\% or 50/63) was higher in the larger babies (800-999 gm) than in the smaller babies (28/63 of the 500-799 gm or 44.4\%, p = 0.0001). Survival rates among the 2 periods, 1990-91 (period 1) and 1992-93 (period 2) have also improved, from 44/74 or 59.5\% to 34/52 or 65.4\%, p = 0.62 (NS). Surfactant replacement therapy (SRT) has an impact on decreasing the mortality for babies < 1,000 gm. Only 35.3\% (6/17) babies had SRT in 1993. Other perinatal factors are also contributing to a better outcome of these high risk babies. Neurodevelopmental outcome at 2 years of age of the 39 babies (50\%) born in period 1 has been determined. Thirty-five percent (5/14) of the smaller babies and 28\% (7/25) of the larger babies had MDI (Bayley Mental Developmental Index) of < 69. For cerebral palsy, it was 14\% and 8\% respectively; and for neurosensory disorder, 7\% and 4\% respectively. Some babies had a combination of 2 or 3 major impairments. It is estimated that 33\% of babies who weighed less than 1,000 gm at birth had a disability. It was found that severe intraventricular haemorrhage (IVH) of grade III and IV correlated significantly with MDI of < 69 (p < 0.05). Severe IVH in period 2 (17.2\%) did not differ significantly from that of period 1 (29.4\%, p = 0.55).(ABSTRACT TRUNCATED AT 250 WORDS)

@article{Ho1995, abstract = {Over a 4-year period (1990-1993) 126 babies weighing 500-999 grams (0.39\% of 32,362 livebirths) were born in the hospital that provides tertiary care. Seventy-eight babies (61.9\%) were discharged alive. Survival rate (79.4\% or 50/63) was higher in the larger babies (800-999 gm) than in the smaller babies (28/63 of the 500-799 gm or 44.4\%, p = 0.0001). Survival rates among the 2 periods, 1990-91 (period 1) and 1992-93 (period 2) have also improved, from 44/74 or 59.5\% to 34/52 or 65.4\%, p = 0.62 (NS). Surfactant replacement therapy (SRT) has an impact on decreasing the mortality for babies < 1,000 gm. Only 35.3\% (6/17) babies had SRT in 1993. Other perinatal factors are also contributing to a better outcome of these high risk babies. Neurodevelopmental outcome at 2 years of age of the 39 babies (50\%) born in period 1 has been determined. Thirty-five percent (5/14) of the smaller babies and 28\% (7/25) of the larger babies had MDI (Bayley Mental Developmental Index) of < 69. For cerebral palsy, it was 14\% and 8\% respectively; and for neurosensory disorder, 7\% and 4\% respectively. Some babies had a combination of 2 or 3 major impairments. It is estimated that 33\% of babies who weighed less than 1,000 gm at birth had a disability. It was found that severe intraventricular haemorrhage (IVH) of grade III and IV correlated significantly with MDI of < 69 (p < 0.05). Severe IVH in period 2 (17.2\%) did not differ significantly from that of period 1 (29.4\%, p = 0.55).(ABSTRACT TRUNCATED AT 250 WORDS)}, added-at = {2014-07-19T20:27:50.000+0200}, author = {Ho, N. K. and Lim, S. B.}, biburl = {https://www.bibsonomy.org/bibtex/23c9818449aa06c832fe45fa464bd4e1d/ar0berts}, groups = {public}, interhash = {ba975a91b2622a6f8e3c9799d3985c5a}, intrahash = {3c9818449aa06c832fe45fa464bd4e1d}, journal = {Singapore Med J}, keywords = {Birth Weight; Brain; Brain Diseases; Bronchopulmonary Dysplasia; Cause of Death; Cerebral Hemorrhage; Palsy; Child Development; Developing Countries; Disabled Persons; Humans; Infant; Infant, Low Newborn; Patient Discharge; Prognosis; Pulmonary Su; Retinopathy Prematurity; Risk Factors; Singapore; Survival Rate; rfactants}, month = Apr, number = 2, pages = {185--188}, pmid = {7676264}, timestamp = {2014-07-19T20:27:50.000+0200}, title = {Outcome of infants weighing 500-999 grams at birth in a Singapore hospital (1990-1993).}, username = {ar0berts}, volume = 36, year = 1995 }