Abstract
The first disesquiterpene coumarin, sanandajin, five sesquiterpene
coumarins, kamolonol acetate, fekrynol acetate, ethyl galbanate, methyl
galbanate, farnesiferol B, and a sesquiterpene, aristolone, were
isolated from a n-hexane extract of Ferula pseudalliacea roots. The
structures were elucidated by 1D and 2D NMR, HR-ESIMS data, and
kamolonol acetate was confirmed by single-crystal X-ray analysis. The
absolute configuration of compounds was established by comparison of
experimental and simulated ECD spectra using time dependence density
function theory (TDDFT). In vitro antiplasmodial activity against
Plasmodium falciparum K1 strain was determined. sanandajin, kamolonol
acetate and methyl galbanate showed moderate antiplasmodial activity,
with IC50 values of 2.6, 16.1 and 7.1 AM, respectively. (C) 2012
Elsevier Ltd. All rights reserved.
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