%0 Journal Article %1 Feathers1977 %A Feathers, R. S. %A Sagor, G. R. %A Lewis, A. A. %A Amirak, I. D. %A Noone, P. %D 1977 %J Lancet %K metronidazole prophylaxis %N 8027 %P 4--8 %R http://dx.doi.org/10.1016/S0140-6736(77)90003-4 %T Prophylactic systemic antibiotics in colorectal surgery. %V 310 %X The prophylactic value of gentamicin combined with either lincomycin or metronidazole in 52 patients undergoing colorectal surgery was investigated. The results confirmed the value of this practice. In a control group, the sepsis-rate was 48\% with 1 death attributable to sepsis, compared with a sepsis-rate of 4\% in the treated group. The combination of gentamicin and lincomycin was effective against sepsis but pseudomembranous colitis developed in 2 of the 14 patients treated with this combination of drugs. Lincomycin was discontinued, and when metronidazole was substituted the results were equally good and there were no toxic side-effects.

@article{Feathers1977, abstract = {The prophylactic value of gentamicin combined with either lincomycin or metronidazole in 52 patients undergoing colorectal surgery was investigated. The results confirmed the value of this practice. In a control group, the sepsis-rate was 48\% with 1 death attributable to sepsis, compared with a sepsis-rate of 4\% in the treated group. The combination of gentamicin and lincomycin was effective against sepsis but pseudomembranous colitis developed in 2 of the 14 patients treated with this combination of drugs. Lincomycin was discontinued, and when metronidazole was substituted the results were equally good and there were no toxic side-effects.}, added-at = {2012-02-28T00:15:32.000+0100}, author = {Feathers, R. S. and Sagor, G. R. and Lewis, A. A. and Amirak, I. D. and Noone, P.}, biburl = {https://www.bibsonomy.org/bibtex/2788efe096b07db73a2a1089badd08899/aorchid}, doi = {http://dx.doi.org/10.1016/S0140-6736(77)90003-4}, groups = {public}, interhash = {23f58b3dbfa53c4b3d5ebfcf84d8e755}, intrahash = {788efe096b07db73a2a1089badd08899}, issue = {8027}, journal = {Lancet}, keywords = {metronidazole prophylaxis}, language = {eng}, medline-pst = {ppublish}, month = Jul, number = 8027, pages = {4--8}, pmid = {69126}, timestamp = {2012-02-28T00:15:32.000+0100}, title = {Prophylactic systemic antibiotics in colorectal surgery.}, username = {aorchid}, volume = 310, year = 1977 }