%0 Journal Article %1 huisun2004augments %A hui Sun, Zhao %A lai Lai, Yan %A Li, Peng %A cong Zuo, Huan %A ping Xie, Zuo %D 2004 %J Cell Biology International %K differentiation gdnf phd stemcell %N 4 %P 323--325 %R 10.1016/j.cellbi.2004.01.006 %T \GDNF\ augments survival and differentiation of TH-positive neurons in neural progenitor cells %U http://www.sciencedirect.com/science/article/pii/S1065699504000472 %V 28 %X \GDNF\ plays an important role in the survival and differentiation of primary dopaminergic neurons, but it requires multiple factors for its entire range of activities. This study investigated the effects of \GDNF\ and its cofactors on the development of bFGF-responsive neural progenitor cells (NPCs), mesencephalic and cortical progenitor cells (MP and CP). Various factors were found to have significant inductive effects on the survival and maintenance of these cells in late developmental stages. \MP\ had greater potential than \CP\ to differentiate into dopaminergic neurons. Treatment of \NPCs\ with \GDNF\ and its cofactors enhanced MAP-2 and Þ\ expression, particularly the latter. These findings suggest that NPCs, particularly MP, could develop into more specific neurons if the appropriate factors were applied during the final cell fate specification. They might thus become beneficial sources of donor cells in the treatment of neurological disorders.

@article{huisun2004augments, abstract = {\{GDNF\} plays an important role in the survival and differentiation of primary dopaminergic neurons, but it requires multiple factors for its entire range of activities. This study investigated the effects of \{GDNF\} and its cofactors on the development of bFGF-responsive neural progenitor cells (NPCs), mesencephalic and cortical progenitor cells (MP and CP). Various factors were found to have significant inductive effects on the survival and maintenance of these cells in late developmental stages. \{MP\} had greater potential than \{CP\} to differentiate into dopaminergic neurons. Treatment of \{NPCs\} with \{GDNF\} and its cofactors enhanced MAP-2 and \{TH\} expression, particularly the latter. These findings suggest that NPCs, particularly MP, could develop into more specific neurons if the appropriate factors were applied during the final cell fate specification. They might thus become beneficial sources of donor cells in the treatment of neurological disorders. }, added-at = {2013-05-21T13:57:53.000+0200}, author = {hui Sun, Zhao and lai Lai, Yan and Li, Peng and cong Zuo, Huan and ping Xie, Zuo}, biburl = {https://www.bibsonomy.org/bibtex/240a8520ce1f2fff9ee0d83d28cbed8fd/bkoch}, description = {ScienceDirect.com - Cell Biology International - GDNF augments survival and differentiation of TH-positive neurons in neural progenitor cells}, doi = {10.1016/j.cellbi.2004.01.006}, interhash = {16eeda81a1109b35e1ae832b2118b136}, intrahash = {40a8520ce1f2fff9ee0d83d28cbed8fd}, issn = {1065-6995}, journal = {Cell Biology International }, keywords = {differentiation gdnf phd stemcell}, number = 4, pages = {323--325}, timestamp = {2013-05-21T13:57:53.000+0200}, title = {\{GDNF\} augments survival and differentiation of TH-positive neurons in neural progenitor cells }, url = {http://www.sciencedirect.com/science/article/pii/S1065699504000472}, volume = 28, year = 2004 }