The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.
%0 Journal Article
%1 Soros:NeurosciLett:2001
%A Sörös, P.
%A Knecht, S.
%A Bantel, C.
%A Imai, T.
%A Wüsten, R.
%A Pantev, C.
%A Lütkenhöner, B.
%A Bürkle, H.
%A Henningsen, H.
%C Ireland
%D 2001
%J Neurosci Lett
%K Cortex;Nerve Disease;Pain;Neuronal Fibers;Evoked Plasticity;Nociceptors;Male;Hand;Adult;Somatosensory Potentials, Somatosensory;Capsaicin gov't;Magnetoencephalography;Humans;Acute non-u.s. research support,
%N 3
%P 195-8
%T Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography.
%V 298
%X The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.
@article{Soros:NeurosciLett:2001,
abstract = {The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to assess whether acute pain by itself causes a reorganization of the primary somatosensory cortex. After the induction of an intense experimental pain at the thenar of the left hand by intradermal injection of capsaicin, the extent of the cortical hand representation and the distance between the hand representation and the localization of the lip decreased. A likely mechanism for this acute reorganization is that pain induced hyperresponsiveness of the left thenar to tactile input from neighboring body sites.},
added-at = {2012-04-29T04:45:51.000+0200},
address = {Ireland},
author = {Sörös, P. and Knecht, S. and Bantel, C. and Imai, T. and Wüsten, R. and Pantev, C. and Lütkenhöner, B. and Bürkle, H. and Henningsen, H.},
biburl = {https://www.bibsonomy.org/bibtex/246321a1d2e5b77eea790b6264b7e4416/asterix},
citation_identifier = {Sörös 2001a},
interhash = {fce08e719c5003333606b40ab1ebc324},
intrahash = {46321a1d2e5b77eea790b6264b7e4416},
issn = {0304-3940},
journal = {Neurosci Lett},
keywords = {Cortex;Nerve Disease;Pain;Neuronal Fibers;Evoked Plasticity;Nociceptors;Male;Hand;Adult;Somatosensory Potentials, Somatosensory;Capsaicin gov't;Magnetoencephalography;Humans;Acute non-u.s. research support,},
month = {2},
number = 3,
organization = {Department of Neurology, University of Münster, Albert Schweitzer-Strasse 33, 48129, Münster, Germany. soros\@uni-muenster.de},
pages = {195-8},
pii = {S0304394000017523},
primary_contributor_role = {Author},
publicationstatus = {Published},
pubmedid = {11165440},
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timestamp = {2012-04-29T04:45:54.000+0200},
title = {Functional reorganization of the human primary somatosensory cortex after acute pain demonstrated by magnetoencephalography.},
us_nlm_id = {7600130},
uuid = {FB34ABF0-29D2-43E7-8A69-2B99CF357A0D},
volume = 298,
web_data_source = {PubMed},
year = 2001
}