The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.
Description
Mapping the antigenic and genetic evolution of inf...[Science. 2004] - PubMed Result
%0 Journal Article
%1 Smith:2004:Science:15218094
%A Smith, D J
%A Lapedes, A S
%A de Jong, J C
%A Bestebroer, T M
%A Rimmelzwaan, G F
%A Osterhaus, A D
%A Fouchier, R A
%D 2004
%J Science
%K antigenic epi evolution imported influenza winmong
%N 5682
%P 371-376
%R 10.1126/science.1097211
%T Mapping the antigenic and genetic evolution of influenza virus
%U http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&orig_db=pubmed&term=smith%20%5Bau%5D%20Mapping%20the%20antigenic%20and%20genetic%20evolution%20of%20influenza%20virus.&cmd=search&src=
%V 305
%X The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.
@article{Smith:2004:Science:15218094,
abstract = {The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.},
added-at = {2009-08-05T20:09:29.000+0200},
author = {Smith, D J and Lapedes, A S and de Jong, J C and Bestebroer, T M and Rimmelzwaan, G F and Osterhaus, A D and Fouchier, R A},
biburl = {https://www.bibsonomy.org/bibtex/24818010c5a08197aa0fa1c5064885e58/ebo},
description = {Mapping the antigenic and genetic evolution of inf...[Science. 2004] - PubMed Result},
doi = {10.1126/science.1097211},
interhash = {970b7b1d4829e6dcbe885d429bd3bf90},
intrahash = {4818010c5a08197aa0fa1c5064885e58},
journal = {Science},
keywords = {antigenic epi evolution imported influenza winmong},
month = Jul,
number = 5682,
pages = {371-376},
pmid = {15218094},
timestamp = {2009-08-05T20:09:29.000+0200},
title = {Mapping the antigenic and genetic evolution of influenza virus},
url = {http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&orig_db=pubmed&term=smith%20%5Bau%5D%20Mapping%20the%20antigenic%20and%20genetic%20evolution%20of%20influenza%20virus.&cmd=search&src=},
volume = 305,
year = 2004
}