Zusammenfassung
The synthesis of 2-(hex-1-ynyl)adenosine derivatives substituted at
the N6- and/or 5'-position was carried out on the basis that 2-(hex-1-ynyl)adenosine-5'-N-ethyluronamide
(HENECA, 2) showed good affinity and different degree of selectivity
for rat adenosine receptors. All new compounds were tested in radioligand
binding and adenylyl cyclase assays with recently cloned human A1,
A2A, A2B, and A3 adenosine receptors.
Nutzer