%0 Journal Article %1 vernot2014resurrecting %A Vernot, Benjamin %A Akey, Joshua M. %D 2014 %J Science %K Neanderthal human_genome introgression %R 10.1126/science.1245938 %T Resurrecting Surviving Neandertal Lineages from Modern Human Genomes %U http://www.sciencemag.org/content/early/2014/01/28/science.1245938.abstract %X Anatomically modern humans overlapped and mated with Neandertals such that non-African humans inherit ~1-3% of their genomes from Neandertal ancestors. We identified Neandertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 European and 286 East Asian individuals, recovering over 15 Gb of introgressed sequence that spans ~20% of the Neandertal genome (FDR = 5%). Analyses of surviving archaic lineages suggests that there were fitness costs to hybridization, admixture occurred both before and subsequent to divergence of non-African modern humans, and Neandertals were a source of adaptive variation for loci involved in skin phenotypes. Our results provide a new avenue for paleogenomics studies, allowing substantial amounts of population-level DNA sequence information to be obtained from extinct groups even in the absence of fossilized remains.

@article{vernot2014resurrecting, abstract = {Anatomically modern humans overlapped and mated with Neandertals such that non-African humans inherit ~1-3% of their genomes from Neandertal ancestors. We identified Neandertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 European and 286 East Asian individuals, recovering over 15 Gb of introgressed sequence that spans ~20% of the Neandertal genome (FDR = 5%). Analyses of surviving archaic lineages suggests that there were fitness costs to hybridization, admixture occurred both before and subsequent to divergence of non-African modern humans, and Neandertals were a source of adaptive variation for loci involved in skin phenotypes. Our results provide a new avenue for paleogenomics studies, allowing substantial amounts of population-level DNA sequence information to be obtained from extinct groups even in the absence of fossilized remains.}, added-at = {2014-01-31T17:46:35.000+0100}, author = {Vernot, Benjamin and Akey, Joshua M.}, biburl = {https://www.bibsonomy.org/bibtex/24917c450d5ad2fa7f6d1de3d0a48d47f/peter.ralph}, doi = {10.1126/science.1245938}, eprint = {http://www.sciencemag.org/content/early/2014/01/28/science.1245938.full.pdf}, interhash = {24c8529b2e992483561043a44a3dc9fd}, intrahash = {4917c450d5ad2fa7f6d1de3d0a48d47f}, journal = {Science}, keywords = {Neanderthal human_genome introgression}, timestamp = {2014-01-31T17:55:20.000+0100}, title = {Resurrecting Surviving Neandertal Lineages from Modern Human Genomes}, url = {http://www.sciencemag.org/content/early/2014/01/28/science.1245938.abstract}, year = 2014 }