The transverse tubules (t-tubules) of mammalian cardiac ventricular
myocytes are invaginations of the surface membrane. Recent studies
have suggested that the structure and function of the t-tubules are
more complex than previously believed; in particular, many of the
proteins involved in cellular Ca$^2+$ cycling appear to be concentrated
at the t-tubule. Thus, the t-tubules are an important determinant
of cardiac cell function, especially as the main site of excitation-contraction
coupling, ensuring spatially and temporally synchronous Ca$^2+$
release throughout the cell. Changes in t-tubule structure and protein
expression occur during development and in heart failure, so that
changes in the t-tubules may contribute to the functional changes
observed in these conditions. The purpose of this review is to provide
an overview of recent studies of t-tubule structure and function
in cardiac myocytes.
%0 Journal Article
%1 Bret_2003_1182
%A Brette, Fabien
%A Orchard, Clive
%D 2003
%J Circ. Res.
%K 12805236 ATPase, Animals, Calcium, Capacitance, Cardiac, Cardiomegaly, Cell Cells, Comparative Congestive, Cultured, Distribution, Electric Failure, Gov't, Guinea Heart Heart, Humans, Ion Mammals, Membrane Mice, Myocytes, Non-U.S. P.H.S., Pigs, Potentials, Proteins, Rabbits, Rats, Research Sarcolemma, Signal Size, Sodium, Study, Support, Swine, Tissue Transduction, Transport, U.S. Ventricles, {N}a$^{+}$-{K}$^{+}$-Exchanging
%N 11
%P 1182--1192
%R 10.1161/01.RES.0000074908.17214.FD
%T T-tubule function in mammalian cardiac myocytes.
%U http://dx.doi.org/10.1161/01.RES.0000074908.17214.FD
%V 92
%X The transverse tubules (t-tubules) of mammalian cardiac ventricular
myocytes are invaginations of the surface membrane. Recent studies
have suggested that the structure and function of the t-tubules are
more complex than previously believed; in particular, many of the
proteins involved in cellular Ca$^2+$ cycling appear to be concentrated
at the t-tubule. Thus, the t-tubules are an important determinant
of cardiac cell function, especially as the main site of excitation-contraction
coupling, ensuring spatially and temporally synchronous Ca$^2+$
release throughout the cell. Changes in t-tubule structure and protein
expression occur during development and in heart failure, so that
changes in the t-tubules may contribute to the functional changes
observed in these conditions. The purpose of this review is to provide
an overview of recent studies of t-tubule structure and function
in cardiac myocytes.
@article{Bret_2003_1182,
abstract = {The transverse tubules (t-tubules) of mammalian cardiac ventricular
myocytes are invaginations of the surface membrane. Recent studies
have suggested that the structure and function of the t-tubules are
more complex than previously believed; in particular, many of the
proteins involved in cellular {C}a$^{2+}$ cycling appear to be concentrated
at the t-tubule. Thus, the t-tubules are an important determinant
of cardiac cell function, especially as the main site of excitation-contraction
coupling, ensuring spatially and temporally synchronous {C}a$^{2+}$
release throughout the cell. Changes in t-tubule structure and protein
expression occur during development and in heart failure, so that
changes in the t-tubules may contribute to the functional changes
observed in these conditions. The purpose of this review is to provide
an overview of recent studies of t-tubule structure and function
in cardiac myocytes.},
added-at = {2009-06-03T11:20:58.000+0200},
author = {Brette, Fabien and Orchard, Clive},
biburl = {https://www.bibsonomy.org/bibtex/252432b371bdefaa9e6a220b57e891cac/hake},
description = {The whole bibliography file I use.},
doi = {10.1161/01.RES.0000074908.17214.FD},
file = {Bret_2003_1182.pdf:Bret_2003_1182.pdf:PDF},
interhash = {48fbd64905e4c476789f846d06d78fe6},
intrahash = {52432b371bdefaa9e6a220b57e891cac},
journal = {Circ. Res.},
key = 53,
keywords = {12805236 ATPase, Animals, Calcium, Capacitance, Cardiac, Cardiomegaly, Cell Cells, Comparative Congestive, Cultured, Distribution, Electric Failure, Gov't, Guinea Heart Heart, Humans, Ion Mammals, Membrane Mice, Myocytes, Non-U.S. P.H.S., Pigs, Potentials, Proteins, Rabbits, Rats, Research Sarcolemma, Signal Size, Sodium, Study, Support, Swine, Tissue Transduction, Transport, U.S. Ventricles, {N}a$^{+}$-{K}$^{+}$-Exchanging},
month = Jun,
number = 11,
pages = {1182--1192},
pii = {92/11/1182},
pmid = {12805236},
timestamp = {2009-06-03T11:21:06.000+0200},
title = {T-tubule function in mammalian cardiac myocytes.},
url = {http://dx.doi.org/10.1161/01.RES.0000074908.17214.FD},
volume = 92,
year = 2003
}