%0 Journal Article %1 Authier2008 %A Authier, Simon %A Tremblay, Sébastien %A Dumulon, Véronique %A Dubuc, Céléna %A Ouellet, René %A Lecomte, Roger %A Cunnane, Stephen C %A Bénard, François %D 2008 %J Mol Imaging Biol %K methods;ProstaticNeoplasms Acetoacetates pharmacokinetics;Animals;CarbonRadioisotopes metabolism/pathology/radionuclideimaging;Mice;Mice Nude;Positron-EmissionTomography Animal InbredBALBC;Mice metabolism/pathology/radionuclideimaging;TissueDistribution;XenograftModelAntitumorAssays;rlecomte Tumor;Female;Humans;Male;MammaryNeoplasms diagnosticuse;CellLine %N 4 %P 217--223 %R 10.1007/s11307-008-0143-6 %T 11C acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice. %U http://dx.doi.org/10.1007/s11307-008-0143-6 %V 10 %X A significant positive correlation has been observed between ketone body availability and their uptake by tumor cells. Our objective was to evaluate 11Cacetoacetate as a potential tracer of ketone body utilization by breast and prostate tumors and to compare it with 11Cacetate.Biodistribution studies were performed with 11Cacetoacetate and 11Cacetate in mice bearing breast or prostate tumors. The percentage of the injected dose accumulated per gram of tissue was determined. These results were complemented by dynamic positron emission tomography (PET) imaging of the radiotracer uptake and dosimetry calculations.11CAcetoacetate uptake was optimal between 5 and 30 min, with maximal uptake of 2.72, 2.42, 2.54, and 2.19\% injected dose (\%ID)/g for MC7-L1, MC4-L2, PC3, and LN-CaP tumors respectively. Tumor retention for 11Cacetoacetate tended to be higher than 11Cacetate, but this did not reach statistical significance. 11CAcetate uptake was reached within 15 min with optimal uptake of 1.25, 2.30, and 0.96\%ID/g for MC7-L1, MC4-L2, and PC-3 tumors, respectively.We observed a moderate uptake of 11Cacetoacetate in breast and prostate tumors with low background activity due to rapid elimination of this tracer. Further studies are warranted to determine if this tracer can detect slow-growing breast and prostate cancers in the clinical setting.

@article{Authier2008, abstract = {A significant positive correlation has been observed between ketone body availability and their uptake by tumor cells. Our objective was to evaluate [11C]acetoacetate as a potential tracer of ketone body utilization by breast and prostate tumors and to compare it with [11C]acetate.Biodistribution studies were performed with [11C]acetoacetate and [11C]acetate in mice bearing breast or prostate tumors. The percentage of the injected dose accumulated per gram of tissue was determined. These results were complemented by dynamic positron emission tomography (PET) imaging of the radiotracer uptake and dosimetry calculations.[11C]Acetoacetate uptake was optimal between 5 and 30 min, with maximal uptake of 2.72, 2.42, 2.54, and 2.19\% injected dose (\%ID)/g for MC7-L1, MC4-L2, PC3, and LN-CaP tumors respectively. Tumor retention for [11C]acetoacetate tended to be higher than [11C]acetate, but this did not reach statistical significance. [11C]Acetate uptake was reached within 15 min with optimal uptake of 1.25, 2.30, and 0.96\%ID/g for MC7-L1, MC4-L2, and PC-3 tumors, respectively.We observed a moderate uptake of [11C]acetoacetate in breast and prostate tumors with low background activity due to rapid elimination of this tracer. Further studies are warranted to determine if this tracer can detect slow-growing breast and prostate cancers in the clinical setting.}, added-at = {2011-07-21T21:30:43.000+0200}, author = {Authier, Simon and Tremblay, Sébastien and Dumulon, Véronique and Dubuc, Céléna and Ouellet, René and Lecomte, Roger and Cunnane, Stephen C and Bénard, François}, biburl = {https://www.bibsonomy.org/bibtex/2549e3ee851b2445d1cbe9decd18803bf/crc_chus}, doi = {10.1007/s11307-008-0143-6}, institution = {Sherbrooke Molecular Imaging Center, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 3001, 12th Avenue N., Sherbrooke, QC, Canada, J1H 5N4. Simon.Authier@Usherbrooke.ca}, interhash = {fb3f35bce78b5ab705061b7c33545f72}, intrahash = {549e3ee851b2445d1cbe9decd18803bf}, journal = {Mol Imaging Biol}, keywords = {methods;ProstaticNeoplasms Acetoacetates pharmacokinetics;Animals;CarbonRadioisotopes metabolism/pathology/radionuclideimaging;Mice;Mice Nude;Positron-EmissionTomography Animal InbredBALBC;Mice metabolism/pathology/radionuclideimaging;TissueDistribution;XenograftModelAntitumorAssays;rlecomte Tumor;Female;Humans;Male;MammaryNeoplasms diagnosticuse;CellLine}, language = {eng}, medline-pst = {ppublish}, number = 4, pages = {217--223}, pmid = {18454299}, timestamp = {2011-07-21T21:30:43.000+0200}, title = {[11C] acetoacetate utilization by breast and prostate tumors: a PET and biodistribution study in mice.}, url = {http://dx.doi.org/10.1007/s11307-008-0143-6}, volume = 10, year = 2008 }