Although pathogenesis of phenylketonuria is not completely
understood, a low phenylalanine diet is effective to
prevent severe neurological impairment, mental retardation
and behavioural difficulties. Treatment recommendations
heavily rely on neuropsychological research; however,
single study results are ambiguous, what is reflected in
substantial variation of US, British, German, Dutch and
French recommendations for blood phenylalanine
concentrations for adolescents and adults. We conducted a
meta-analysis estimating the influence of age,
phenylalanine level, and type of neuropsychological test on
effect sizes (standardized differences between controls and
patients) of computer-based speed measurements in
phenylketonuric patients. The effect of blood phenylalanine
level on effect size was more pronounced in children and
adolescents than in adults, with choice reaction time being
particularly sensitive for phenylalanine concentrations.
Results corroborate all recommendations for children. With
the exception of the US and Dutch recommendations, all
recommendations for adolescents seem to be too liberal. The
same effect size is predicted for adult phenylalanine
concentrations between 750 and 1500mumol/L not suggesting a
prefile:///home/sfg/Desktop/pubmed_result(2).txt ference
for any of the published treatment recommendations for
adulthood.
%0 Journal Article
%1 albrecht.garbade.ea:neuropsychological
%A Albrecht, Julia
%A Garbade, Sven F
%A Burgard, Peter
%D 2009
%J Neurosci Biobehav Rev
%K imported sfg
%N 3
%P 414--421
%R 10.1016/j.neubiorev.2008.11.001
%T Neuropsychological speed tests and blood phenylalanine
levels in patients with phenylketonuria: A meta-analysis.
%U http://dx.doi.org/10.1016/j.neubiorev.2008.11.001
%V 33
%X Although pathogenesis of phenylketonuria is not completely
understood, a low phenylalanine diet is effective to
prevent severe neurological impairment, mental retardation
and behavioural difficulties. Treatment recommendations
heavily rely on neuropsychological research; however,
single study results are ambiguous, what is reflected in
substantial variation of US, British, German, Dutch and
French recommendations for blood phenylalanine
concentrations for adolescents and adults. We conducted a
meta-analysis estimating the influence of age,
phenylalanine level, and type of neuropsychological test on
effect sizes (standardized differences between controls and
patients) of computer-based speed measurements in
phenylketonuric patients. The effect of blood phenylalanine
level on effect size was more pronounced in children and
adolescents than in adults, with choice reaction time being
particularly sensitive for phenylalanine concentrations.
Results corroborate all recommendations for children. With
the exception of the US and Dutch recommendations, all
recommendations for adolescents seem to be too liberal. The
same effect size is predicted for adult phenylalanine
concentrations between 750 and 1500mumol/L not suggesting a
prefile:///home/sfg/Desktop/pubmed_result(2).txt ference
for any of the published treatment recommendations for
adulthood.
@article{albrecht.garbade.ea:neuropsychological,
abstract = {Although pathogenesis of phenylketonuria is not completely
understood, a low phenylalanine diet is effective to
prevent severe neurological impairment, mental retardation
and behavioural difficulties. Treatment recommendations
heavily rely on neuropsychological research; however,
single study results are ambiguous, what is reflected in
substantial variation of US, British, German, Dutch and
French recommendations for blood phenylalanine
concentrations for adolescents and adults. We conducted a
meta-analysis estimating the influence of age,
phenylalanine level, and type of neuropsychological test on
effect sizes (standardized differences between controls and
patients) of computer-based speed measurements in
phenylketonuric patients. The effect of blood phenylalanine
level on effect size was more pronounced in children and
adolescents than in adults, with choice reaction time being
particularly sensitive for phenylalanine concentrations.
Results corroborate all recommendations for children. With
the exception of the US and Dutch recommendations, all
recommendations for adolescents seem to be too liberal. The
same effect size is predicted for adult phenylalanine
concentrations between 750 and 1500mumol/L not suggesting a
prefile:///home/sfg/Desktop/pubmed_result(2).txt ference
for any of the published treatment recommendations for
adulthood.},
added-at = {2017-04-01T10:34:58.000+0200},
author = {Albrecht, Julia and Garbade, Sven F and Burgard, Peter},
biburl = {https://www.bibsonomy.org/bibtex/255068f4d2d94e3f8363ce067d286d211/sveng},
doi = {10.1016/j.neubiorev.2008.11.001},
interhash = {a96c059ffb72cbb5e32e79af84f937af},
intrahash = {55068f4d2d94e3f8363ce067d286d211},
journal = {Neurosci Biobehav Rev},
keywords = {imported sfg},
month = Mar,
number = 3,
owner = {sfg},
pages = {414--421},
pii = {S0149-7634(08)00189-9},
pmid = {19038285},
timestamp = {2017-04-01T10:35:16.000+0200},
title = {Neuropsychological speed tests and blood phenylalanine
levels in patients with phenylketonuria: A meta-analysis.},
url = {http://dx.doi.org/10.1016/j.neubiorev.2008.11.001},
volume = 33,
year = 2009
}