Recent guidelines recommend antiretroviral therapy (ART) to be administered as early as possible during HIV-1 infection. Few studies addressed the immunological benefit of commencing ART during the acute phase of infection. We used mass cytometry to characterize blood CD4+ T cells from HIV-1-infected patients who initiated ART during acute or chronic phase of infection. Using this method, we analyzed a large number of markers on millions of individual immune cells. The results revealed that CD4+ T cell clusters with high expression of CD27, CD28, CD127, and CD44, whose function involves T cell migration to inflamed tissues and survival, are more abundant in healthy controls and patients initiating ART during the acute phase; on the contrary, CD4+ T cell clusters in patients initiating ART during the chronic phase had reduced expression of these markers. The results are suggestive of a better preserved immune function in HIV-1-infected patients initiating ART during acute infection.
Описание
Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1–infected patients according to antiretroviral therapy initiation
%0 Journal Article
%1 noauthororeditor
%A Bekele, Yonas
%A Lakshmikanth, Tadepally
%A Chen, Yang
%A Mikes, Jaromir
%A Nasi, Aikaterini
%A Petkov, Stefan
%A Hejdeman, Bo
%A Brodin, Petter
%A Chiodi, Francesca
%D 2019
%J JCI insight
%K HIV
%N 3
%R 10.1172/jci.insight.125442
%T Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.
%V 4
%X Recent guidelines recommend antiretroviral therapy (ART) to be administered as early as possible during HIV-1 infection. Few studies addressed the immunological benefit of commencing ART during the acute phase of infection. We used mass cytometry to characterize blood CD4+ T cells from HIV-1-infected patients who initiated ART during acute or chronic phase of infection. Using this method, we analyzed a large number of markers on millions of individual immune cells. The results revealed that CD4+ T cell clusters with high expression of CD27, CD28, CD127, and CD44, whose function involves T cell migration to inflamed tissues and survival, are more abundant in healthy controls and patients initiating ART during the acute phase; on the contrary, CD4+ T cell clusters in patients initiating ART during the chronic phase had reduced expression of these markers. The results are suggestive of a better preserved immune function in HIV-1-infected patients initiating ART during acute infection.
@article{noauthororeditor,
abstract = {Recent guidelines recommend antiretroviral therapy (ART) to be administered as early as possible during HIV-1 infection. Few studies addressed the immunological benefit of commencing ART during the acute phase of infection. We used mass cytometry to characterize blood CD4+ T cells from HIV-1-infected patients who initiated ART during acute or chronic phase of infection. Using this method, we analyzed a large number of markers on millions of individual immune cells. The results revealed that CD4+ T cell clusters with high expression of CD27, CD28, CD127, and CD44, whose function involves T cell migration to inflamed tissues and survival, are more abundant in healthy controls and patients initiating ART during the acute phase; on the contrary, CD4+ T cell clusters in patients initiating ART during the chronic phase had reduced expression of these markers. The results are suggestive of a better preserved immune function in HIV-1-infected patients initiating ART during acute infection.},
added-at = {2020-04-02T19:07:19.000+0200},
author = {Bekele, Yonas and Lakshmikanth, Tadepally and Chen, Yang and Mikes, Jaromir and Nasi, Aikaterini and Petkov, Stefan and Hejdeman, Bo and Brodin, Petter and Chiodi, Francesca},
biburl = {https://www.bibsonomy.org/bibtex/25a2f809501e10eb65bd14d49fc81b18b/lkanth},
description = {Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1–infected patients according to antiretroviral therapy initiation},
doi = {10.1172/jci.insight.125442},
interhash = {8a6713b8e90fd02bf25955203229cc54},
intrahash = {5a2f809501e10eb65bd14d49fc81b18b},
issn = {2379-3708},
journal = {JCI insight},
keywords = {HIV},
month = {February},
number = 3,
timestamp = {2020-04-02T19:07:19.000+0200},
title = {Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.},
volume = 4,
year = 2019
}