%0 Journal Article %1 Horn.2009 %A Horn, Lars-Christian %A Hentschel, Bettina %A Meinel, Alexandra %A Alexander, Henry %A Leo, Cornelia %D 2009 %J Annals of diagnostic pathology %K Cell_Proliferation Chi-Square_Distribution Cyclooxygenase_2/metabolism Endometriosis/metabolism/pathology Female Humans Immunohistochemistry Ki-67_Antigen/metabolism Neovascularization,_Pathologic/metabolism Ovarian_Diseases/metabolism/pathology Peritoneal_Diseases/metabolism/pathology Statistics,_Nonparametric Uterine_Diseases/metabolism/pathology %N 6 %P 373–377 %T Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions %V 13 %X There is a suggested pathogenetic role of cyclooxygenase-2 (COX-2) in endometriosis via angiogenesis and proproliferative mechanisms. The aim of the study was to investigate the immunohistochemical COX-2 expression in different anatomical sites of endometriosis and its correlation to proliferative activity and periendometriotic vascularization. Sixty endometrioses from different sites (ovarian, uterine, and peritoneal) were evaluated immunohistochemically for COX-2 expression. Cyclooxygenase-2 staining of 75\% or more of the cells was defined as COX-2 overexpression and used as cutoff. Proliferative activity was determined by performing Ki-67-labeling index. Periendometriotic vascularization was evaluated by determining microvessel density surrounding the endometriotic focus using CD-34-immunostaining. Cyclooxygenase-2 overexpression was significant more frequent in ovarian endometriosis, when compared with uterine and peritoneal localization (70.8\% versus 41.7\%; P = .027). There was no significant correlation between COX-2 overexpression and perifocal neovascularization (P = .49). Endometriotic lesions with COX-2 overexpression represented reduced proliferative activity (P = .055). Cyclooxygenase-2 is expressed in the majority of endometriosis, but differences exist within the frequency of overexpression at different anatomical sites of the endometriosis. Cyclooxygenase-2 inhibitors are of clinical interest as treatment options.

@article{Horn.2009, abstract = {There is a suggested pathogenetic role of cyclooxygenase-2 (COX-2) in endometriosis via angiogenesis and proproliferative mechanisms. The aim of the study was to investigate the immunohistochemical COX-2 expression in different anatomical sites of endometriosis and its correlation to proliferative activity and periendometriotic vascularization. Sixty endometrioses from different sites (ovarian, uterine, and peritoneal) were evaluated immunohistochemically for COX-2 expression. Cyclooxygenase-2 staining of 75\% or more of the cells was defined as COX-2 overexpression and used as cutoff. Proliferative activity was determined by performing Ki-67-labeling index. Periendometriotic vascularization was evaluated by determining microvessel density surrounding the endometriotic focus using CD-34-immunostaining. Cyclooxygenase-2 overexpression was significant more frequent in ovarian endometriosis, when compared with uterine and peritoneal localization (70.8\% versus 41.7\%; P = .027). There was no significant correlation between COX-2 overexpression and perifocal neovascularization (P = .49). Endometriotic lesions with COX-2 overexpression represented reduced proliferative activity (P = .055). Cyclooxygenase-2 is expressed in the majority of endometriosis, but differences exist within the frequency of overexpression at different anatomical sites of the endometriosis. Cyclooxygenase-2 inhibitors are of clinical interest as treatment options.}, added-at = {2014-10-15T15:03:55.000+0200}, author = {Horn, Lars-Christian and Hentschel, Bettina and Meinel, Alexandra and Alexander, Henry and Leo, Cornelia}, biburl = {https://www.bibsonomy.org/bibtex/25b215e7701ca8d4cde38320bc622e9a5/drtester}, interhash = {35c75790776c880a362999a4d9ac532b}, intrahash = {5b215e7701ca8d4cde38320bc622e9a5}, journal = {Annals of diagnostic pathology}, keywords = {Cell_Proliferation Chi-Square_Distribution Cyclooxygenase_2/metabolism Endometriosis/metabolism/pathology Female Humans Immunohistochemistry Ki-67_Antigen/metabolism Neovascularization,_Pathologic/metabolism Ovarian_Diseases/metabolism/pathology Peritoneal_Diseases/metabolism/pathology Statistics,_Nonparametric Uterine_Diseases/metabolism/pathology}, number = 6, pages = {373–377}, timestamp = {2014-10-15T15:03:55.000+0200}, title = {Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions}, volume = 13, year = 2009 }