We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.
Description
How complete are current yeast and human protein-i...[Genome Biol. 2006] - PubMed Result
%0 Journal Article
%1 Hart2006
%A Hart, G T
%A Ramani, A K
%A Marcotte, E M
%D 2006
%J Genome Biol
%K WP PPI AP
%N 11
%P 120-120
%R 10.1186/gb-2006-7-11-120
%T How complete are current yeast and human protein-interaction networks?
%U http://www.ncbi.nlm.nih.gov/pubmed/17147767?ordinalpos=
%V 7
%X We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.
@article{Hart2006,
abstract = {We estimate the full yeast protein-protein interaction network to contain 37,800-75,500 interactions and the human network 154,000-369,000, but owing to a high false-positive rate, current maps are roughly only 50% and 10% complete, respectively. Paradoxically, releasing raw, unfiltered assay data might help separate true from false interactions.},
added-at = {2009-10-21T07:57:38.000+0200},
author = {Hart, G T and Ramani, A K and Marcotte, E M},
biburl = {https://www.bibsonomy.org/bibtex/2602ed173583640c859452f600d20c567/penkib},
description = {How complete are current yeast and human protein-i...[Genome Biol. 2006] - PubMed Result},
doi = {10.1186/gb-2006-7-11-120},
interhash = {9b311ba4d679ae26e2a2d243350456cc},
intrahash = {602ed173583640c859452f600d20c567},
journal = {Genome Biol},
keywords = {WP PPI AP},
number = 11,
pages = {120-120},
pmid = {17147767},
timestamp = {2009-10-21T07:57:39.000+0200},
title = {How complete are current yeast and human protein-interaction networks?},
url = {http://www.ncbi.nlm.nih.gov/pubmed/17147767?ordinalpos=},
volume = 7,
year = 2006
}